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[博德特氏菌活疫苗对猪萎缩性鼻炎的发生、表现及该病原菌田间菌株空气传播感染负荷的影响]

[The effect of a Bordetella live vaccine on the occurrence and manifestation of atrophic rhinitis suum and the aerogenous infection burden in field strains of the agent].

作者信息

Ehser U, Mehlhorn G, Mietke H

机构信息

Institut für Tierhygiene, Veterinärmedizinischen Fakultät, Universität Leipzig.

出版信息

Dtsch Tierarztl Wochenschr. 1993 Sep;100(9):355-9.

PMID:8223236
Abstract

A field study was carried out in a large scale unit for swine breeding and fattening with the object to influence the high morbidity rate of Atrophic Rhinitis and pneumonia with the help of a Bordetella live vaccine. The results show that it is possible to decrease the infectious pressure by B. bronchiseptica and to reduce the pathomorphological signs of Atrophic Rhinitis in consequence of the application of the live vaccine. The pathologic-anatomical investigations of nasal turbinates in immunized slaughtered fattening pigs show a significant lower morbidity concerning Atrophic Rhinitis and a higher percentage of pigs without changes at conchae nasales and septum nasi. We find also a lower contamination of the air with B. bronchiseptica field strains during vaccine application. The results also explain that a high infectious pressure by B. bronchiseptica and the possibility of communication between unvaccinated and vaccinated groups of pigs counteract a better efficiency of the vaccine. The decrease of the morbidity rate of Atrophic Rhinitis appears so much more important because toxicogenic Pasteurella multocida strains were isolated from nasal swabs of vaccinated pigs during the investigations. But these strains influenced the Atrophic Rhinitis frequency only accidentally. All results as a whole point out that in pig houses with a high animal density one has to pay more attention to virulent B. bronchiseptica strains than it was been done till now.

摘要

在一个大型生猪养殖育肥场进行了一项实地研究,目的是借助支气管败血波氏杆菌活疫苗来影响萎缩性鼻炎和肺炎的高发病率。结果表明,通过使用活疫苗,可以降低支气管败血波氏杆菌的感染压力,并减少萎缩性鼻炎的病理形态学症状。对免疫后的育肥猪屠宰后鼻甲进行的病理解剖学调查显示,萎缩性鼻炎的发病率显著降低,鼻甲和鼻中隔无变化的猪的比例更高。我们还发现,在疫苗接种期间,空气中支气管败血波氏杆菌野毒株的污染程度较低。结果还表明,支气管败血波氏杆菌的高感染压力以及未接种疫苗和接种疫苗的猪群之间传播的可能性,抵消了疫苗更好的效果。萎缩性鼻炎发病率的降低显得更为重要,因为在调查期间从接种疫苗的猪的鼻拭子中分离出了产毒素多杀性巴氏杆菌菌株。但这些菌株只是偶然影响了萎缩性鼻炎的发病率。总体而言,所有结果都表明,在动物密度高的猪舍中,必须比目前更加关注强毒支气管败血波氏杆菌菌株。

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