Persson B, Axelsson B, Jacobsson H
Department of Diagnostic Radiology, Karolinska Hospital, Stockholm, Sweden.
Eur J Nucl Med. 1993 Sep;20(9):770-5. doi: 10.1007/BF00180907.
Benign papillary stenosis (BPS) is an uncommon condition, the diagnosis of which is often difficult. In this report cholescintigraphy with technetium-99m diethyl-acetanilido-iminodiacetic acid has been evaluated for the diagnosis of BPS, as well as for assessing the effect of treatment by endoscopic sphincterotomy (ES). In 12 patients with BPS, cholescintigraphy was performed before and after ES and the findings compared with those in ten controls. Time-activity curves from regions over the liver and bowel were generated. A significant difference was found in respect of the time for maximum activity (Tmax) over the liver before and after ES. The time for occurrence of bowel activity (Texcr) also showed significant differences before and after ES. Considering both Tmax and Texcr mean values plus two standard deviations in the control group, all BPS patients would have been detected and there would have been no false-positives among the controls. It is concluded that cholescintigraphy should be used in the diagnosis of BPS. The method has high sensitivity and should be applied as an early diagnostic procedure to exclude BPS in patients with clinical suspicion of the disorder. The method can also be used for assessment of endoscopic treatment (ES).
良性乳头狭窄（BPS）是一种罕见疾病，其诊断往往困难。在本报告中，对使用锝-99m二乙乙酰苯胺亚氨基二乙酸进行的肝胆闪烁显像用于BPS诊断以及评估内镜括约肌切开术（ES）治疗效果进行了评估。对12例BPS患者在ES前后进行了肝胆闪烁显像，并将结果与10例对照者的结果进行比较。生成了肝脏和肠道区域的时间-活性曲线。发现ES前后肝脏最大活性时间（Tmax）存在显著差异。肠道活性出现时间（Texcr）在ES前后也显示出显著差异。考虑对照组中Tmax和Texcr的平均值加两个标准差，所有BPS患者均可被检测出，且对照组中不会出现假阳性。结论是肝胆闪烁显像应用于BPS的诊断。该方法具有高灵敏度，应作为早期诊断程序用于排除临床怀疑患有该疾病的患者中的BPS。该方法还可用于评估内镜治疗（ES）。
