Donaldson I M, Knox P C
Department of Pharmacology, University of Edinburgh, UK.
Exp Brain Res. 1993;95(2):240-50. doi: 10.1007/BF00229782.
The role of extraocular muscle (EOM) afferent feedback signals in the control of eye movement is still controversial. We recorded from 106 single units in the vestibular nuclei, oculomotor nuclei and reticular formation of 80 decerebrate, paralysed pigeons. EOM afferents were stimulated by passive eye movement (PEM) during vestibular stimulation by sinusoidal oscillation in the horizontal plane. We found that EOM afferent signals profoundly modified the vestibular responses of 91 (86%) of the single units recorded. As well as using PEM to simulate eye movements similar to saccades, we moved the eye in a manner which mimicked the slow phase of the vestibulo-ocular reflex (artificial VOR, AVOR). We have found evidence that, as well as providing signals closely related to the parameters of eye movement, PEM alters the vestibular responses of cells during AVOR in a manner which suggests that EOM afferent signals may play a corrective role in the moment-to-moment control of eye movement in the vestibulo-ocular reflex.
眼外肌（EOM）传入反馈信号在眼球运动控制中的作用仍存在争议。我们记录了80只去大脑、瘫痪鸽子的前庭核、动眼神经核和网状结构中的106个单神经元活动。在水平面上通过正弦振荡进行前庭刺激期间，通过被动眼动（PEM）刺激眼外肌传入神经。我们发现，眼外肌传入信号深刻地改变了所记录的91个（86%）单神经元的前庭反应。除了使用被动眼动来模拟类似于扫视的眼球运动外，我们还以模仿前庭眼反射（人工VOR，AVOR）慢相的方式移动眼球。我们发现有证据表明，被动眼动除了提供与眼球运动参数密切相关的信号外，还以一种表明眼外肌传入信号可能在前庭眼反射中眼球运动的即时控制中起校正作用的方式改变了AVOR期间细胞的前庭反应。
