Joneja M, Reifel C W, Murphy M L, Shin S H
Department of Anatomy, Queen's University, Kingston, Ontario, Canada.
Experientia. 1993 Oct 15;49(10):836-9. doi: 10.1007/BF01952593.
Cultured mammotropes incubated with dopamine for one hour exhibited changes in ultrastructure indicative of actively depressed biosynthetic and secretory activity. Peripheral relocation of rough endoplasmic reticulum appeared to create a barrier to secretory granule release by exocytosis. A decrease in the numbers of secretory granules indicated a decrease in prolactin production and enhanced lysosomal activity.
