Castellano C, Filibeck L, Oliverio A
Psychopharmacology (Berl). 1976 Aug 26;49(1):29-31. doi: 10.1007/BF00427467.
The locomotor activity of C57Bl/6J and DBA/2J mice was studied, under the influences of heroin, amphetamine, strychnine, or ethanol, and of combinations of the opiate with each one of the other drugs. Heroin treatment was followed by the typical "running fit" in the C57 mice, while the DBA strain was unaffected. Amphetamine enhanced the activity in the C57 strain only. The combination of heroin with amphetamine or ethanol increased the locomotor activity only in the DBA strain, while heroin + strychnine exerted a clear stimulating effect on the activity of the C57 mice. The strychnine + heroin mixture was more toxic than heroin alone when the lethal doses (LD50) were determined in the 2 strains.
研究了海洛因、苯丙胺、士的宁或乙醇以及阿片类药物与其他每种药物的组合对C57Bl/6J和DBA/2J小鼠运动活动的影响。海洛因治疗后，C57小鼠出现典型的“奔跑发作”，而DBA品系未受影响。苯丙胺仅增强了C57品系的活动。海洛因与苯丙胺或乙醇的组合仅增加了DBA品系的运动活动，而海洛因 + 士的宁对C57小鼠的活动有明显的刺激作用。当在这两个品系中测定致死剂量（LD50）时，士的宁 + 海洛因混合物比单独使用海洛因毒性更大。
