文献检索，用中文搜 PubMed

Suppr 超能文献

核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Department of Diagnostic Radiology, University of Wales College of Medicine, Heath Park, Cardiff.

Gen Pharmacol. 1993 Jul;24(4):797-804. doi: 10.1016/0306-3623(93)90152-n.

Pre-existing collateral vessels provide an alternative route for blood flow following acute arterial occlusion. 2. In a novel model of acute arterial occlusion in the isolated rabbit ear vascular bed the development and maintenance of collateral perfusion has an obligatory dependence on endothelium-derived relaxing factor (EDRF) activity. 3. This endothelium-dependent mechanism is severely impaired in dietary-induced hypercholesterolaemia, leading to substantially reduced collateral perfusion. 4. Collateral perfusion may also be influenced by vasodilators, specifically in the rabbit ear model the potassium channel opener BRL 38227 greatly enhances perfusion, sodium nitroprusside (an exogenous analogue of EDRF) has early but limited beneficial effects while verapamil is without effect.

预先存在的侧支血管为急性动脉闭塞后血流提供了一条替代途径。2. 在离体兔耳血管床急性动脉闭塞的新模型中，侧支灌注的形成和维持必然依赖于内皮源性舒张因子（EDRF）活性。3. 这种内皮依赖性机制在饮食诱导的高胆固醇血症中严重受损，导致侧支灌注显著减少。4. 侧支灌注也可能受血管扩张剂影响，特别是在兔耳模型中，钾通道开放剂BRL 38227可大大增强灌注，硝普钠（一种EDRF的外源性类似物）有早期但有限的有益作用，而维拉帕米则无作用。

Department of Diagnostic Radiology, University of Wales College of Medicine, Heath Park, Cardiff.

Gen Pharmacol. 1993 Jul;24(4):797-804. doi: 10.1016/0306-3623(93)90152-n.

Pre-existing collateral vessels provide an alternative route for blood flow following acute arterial occlusion. 2. In a novel model of acute arterial occlusion in the isolated rabbit ear vascular bed the development and maintenance of collateral perfusion has an obligatory dependence on endothelium-derived relaxing factor (EDRF) activity. 3. This endothelium-dependent mechanism is severely impaired in dietary-induced hypercholesterolaemia, leading to substantially reduced collateral perfusion. 4. Collateral perfusion may also be influenced by vasodilators, specifically in the rabbit ear model the potassium channel opener BRL 38227 greatly enhances perfusion, sodium nitroprusside (an exogenous analogue of EDRF) has early but limited beneficial effects while verapamil is without effect.

预先存在的侧支血管为急性动脉闭塞后血流提供了一条替代途径。2. 在离体兔耳血管床急性动脉闭塞的新模型中，侧支灌注的形成和维持必然依赖于内皮源性舒张因子（EDRF）活性。3. 这种内皮依赖性机制在饮食诱导的高胆固醇血症中严重受损，导致侧支灌注显著减少。4. 侧支灌注也可能受血管扩张剂影响，特别是在兔耳模型中，钾通道开放剂BRL 38227可大大增强灌注，硝普钠（一种EDRF的外源性类似物）有早期但有限的有益作用，而维拉帕米则无作用。