Auletta F J, Caldwell B V, Speroff L
Prostaglandins. 1976 Apr;11(4):745-52. doi: 10.1016/0090-6980(76)90074-5.
Normally cycling Rhesus monkeys were treated with diethylstilbestrol (25 mg/day) alone or in combination with indomethacin (25 mg/day) for five consecutive days beginning in the early luteal and mid-luteal phase of the menstrual cycle. Blood specimens were obtained daily to monitor corpus luteum function (progesterone), and the length of each menstrual cycle was recorded. Diethylstilbestrol alone cause premature luteolysis as indicated by decreasing plasma progesterone and shortened menstrual cycle, and indomethacin effectively blocked the luteolytic action of diethylstilbestrol. These results suggest that the probable mechanism of diethylstilbestrol action in causing luteolysis is mediated via the prostaglandins.
正常处于发情周期的恒河猴在月经周期的黄体早期和黄体中期开始，单独使用己烯雌酚（25毫克/天）或与吲哚美辛（25毫克/天）联合使用，连续五天。每天采集血样以监测黄体功能（孕酮），并记录每个月经周期的长度。单独使用己烯雌酚会导致黄体过早溶解，表现为血浆孕酮水平下降和月经周期缩短，而吲哚美辛有效地阻断了己烯雌酚的黄体溶解作用。这些结果表明，己烯雌酚导致黄体溶解的可能作用机制是通过前列腺素介导的。
