Faraway J J
Department of Statistics, University of Michigan, Ann Arbor 48109.
Genet Epidemiol. 1993;10(4):225-33. doi: 10.1002/gepi.1370100403.
An improved sib-pair test for linkage is introduced which is superior to the previously proposed tests. The test is derived from the standard chi-squared goodness of fit statistic by restricting the alternative hypothesis to the genetically possible. Critical values are given and exact power comparisons are made with the previously proposed tests. The new test is shown to be more powerful for finite samples as well as being asymptotically uniformly most powerful.
本文介绍了一种改进的连锁分析同胞对检验方法，该方法优于先前提出的检验方法。该检验是通过将备择假设限制在遗传可能性范围内，从标准卡方拟合优度统计量推导而来。文中给出了临界值，并与先前提出的检验方法进行了精确的功效比较。结果表明，新检验方法在有限样本情况下更具功效，并且在渐近意义上是一致最具功效的。
