Ghosh M, Babu S P, Sukul N C, Mahato S B
Department of Zoology, Visva-Bharati University, India.
Indian J Exp Biol. 1993 Jul;31(7):604-6.
The active principle, isolated from the funicles of A. auriculiformis, consisted of two triterpenoid saponins, acaciaside A and acaciaside B which killed in vitro 97% microfilaria of Setaria cervi in 100 min at 4mg/ml concentration and 100% of adults in 35 min. The drug, when administered orally at 100 mg/kg on rats, in which S. cervi adults were implanted intra-peritoneally, increased the blood mf count by 1.5-fold after the first phase of treatment for 10 days. Following the third phase of treatment and thereafter, the mf density was reduced by more than 80%. No toxic effect of the saponins was observed in rats. The rise in mf count indicated that the drug induced a very high physiological stress on the adult worms which increased the rate of discharge of the mf before impending death. The treated rats on autopsy did not show any adult worms.
从耳叶相思树的珠柄中分离出的活性成分由两种三萜皂苷组成，即阿拉伯糖苷A和阿拉伯糖苷B，它们在体外4mg/ml浓度下100分钟内可杀死97%的鹿丝状线虫微丝蚴，35分钟内可杀死100%的成虫。该药物以100mg/kg的剂量口服给予腹腔植入鹿丝状线虫成虫的大鼠，在为期10天的第一阶段治疗后，血液中的微丝蚴计数增加了1.5倍。在第三阶段治疗及之后，微丝蚴密度降低了80%以上。在大鼠中未观察到皂苷的毒性作用。微丝蚴计数的增加表明该药物对成虫产生了非常高的生理应激，这增加了微丝蚴在即将死亡前的排出率。经治疗的大鼠尸检未发现任何成虫。
