Amin R J, Venkatakrishna-Bhatt H, Panchal G M
Department of Agricultural Health, National Institute of Occupational Health, Meghani Nagar, Ahmedabad.
Indian J Physiol Pharmacol. 1993 Apr;37(2):115-20.
Rats exposed to lead (lead acetate) in doses of 0.2 and 0.5 mg/ml in drinking water for a period of 90 days showed mild to moderate changes in food consumption compared to control group. Drug interactions in lead exposed rats with metoclopramide, atropine sulphate, propranolol, cyproheptadine and mepyramine maleate when administered intraperitoneally caused -30 to +30 percentage variation in food intake indicating the influence of adrenergic, serotonergic and cholinergic neurotransmitters with no change in mean body weight of lead treated rats.
饮用水中铅（醋酸铅）剂量为0.2和0.5毫克/毫升的大鼠，在90天的时间里，与对照组相比，食物消耗量出现了轻度到中度的变化。给铅暴露大鼠腹腔注射胃复安、硫酸阿托品、普萘洛尔、赛庚啶和马来酸氯苯那敏后，药物相互作用导致食物摄入量有-30%至+30%的变化，这表明肾上腺素能、血清素能和胆碱能神经递质产生了影响，而铅处理大鼠的平均体重没有变化。
