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肉毒杆菌C2毒素对虹鳟鱼（Oncorhynchus mykiss）肌动蛋白的ADP核糖基化作用。

ADP-ribosylation of rainbow trout (Oncorhynchus mykiss) actin by botulinum C2 toxin.

作者信息

Kodama H, Ohishi I

机构信息

Department of Veterinary Science, College of Agriculture, University of Osaka Prefecture, Japan.

出版信息

Infect Immun. 1993 Dec;61(12):5392-3. doi: 10.1128/iai.61.12.5392-5393.1993.

DOI:10.1128/iai.61.12.5392-5393.1993
PMID:8225613
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC281328/
Abstract

Intracellular actin of rainbow trout macrophages was ADP-ribosylated by botulinum C2 toxin, which is composed of two nonlinked protein components, component I and trypsinized component II. The actin in the supernatants of various tissue homogenates of the trout was also directly ADP-ribosylated by component I of C2 toxin, indicating that fish actin other than those of land vertebrates is susceptible to enzymatic modification by component I of C2 toxin.

摘要

虹鳟巨噬细胞的细胞内肌动蛋白被肉毒杆菌C2毒素进行了ADP核糖基化，该毒素由两个非连接的蛋白质成分组成，即成分I和经胰蛋白酶处理的成分II。虹鳟各种组织匀浆上清液中的肌动蛋白也被C2毒素的成分I直接进行了ADP核糖基化，这表明除陆地脊椎动物外的鱼类肌动蛋白易受C2毒素成分I的酶促修饰。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7749/281328/6afc0ed5a2df/iai00024-0463-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7749/281328/6afc0ed5a2df/iai00024-0463-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7749/281328/6afc0ed5a2df/iai00024-0463-a.jpg

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本文引用的文献

1
Activation of rainbow trout (Oncorhynchus mykiss) phagocytes by muramyl dipeptide.胞壁酰二肽对虹鳟（Oncorhynchus mykiss）吞噬细胞的激活作用。
Dev Comp Immunol. 1993 Mar-Apr;17(2):129-40. doi: 10.1016/0145-305x(93)90023-j.
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Purification and characterization of two components of botulinum C2 toxin.肉毒杆菌C2毒素两种成分的纯化与特性分析
Infect Immun. 1980 Dec;30(3):668-73. doi: 10.1128/iai.30.3.668-673.1980.
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Response of mouse intestinal loop to botulinum C2 toxin: enterotoxic activity induced by cooperation of nonlinked protein components.
小鼠肠袢对肉毒杆菌C2毒素的反应：非连接蛋白成分协同诱导的肠毒素活性
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Phagocytic activity of macrophages of rainbow trout against Vibrio anguillarum and the opsonising effect of antibody and complement.虹鳟巨噬细胞对鳗弧菌的吞噬活性以及抗体和补体的调理作用。
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Activation of botulinum C2 toxin by trypsin.胰蛋白酶对肉毒杆菌C2毒素的激活作用。
Infect Immun. 1987 Jun;55(6):1461-5. doi: 10.1128/iai.55.6.1461-1465.1987.
7
ADP-ribosylation of nonmuscle actin with component I of C2 toxin.用C2毒素的组分I对非肌肉肌动蛋白进行ADP核糖基化修饰。
Biochem Biophys Res Commun. 1986 Apr 29;136(2):802-6. doi: 10.1016/0006-291x(86)90511-5.
8
Botulinum C2 toxin ADP-ribosylates cytoplasmic beta/gamma-actin in arginine 177.
J Biol Chem. 1988 Jan 15;263(2):696-700.
9
Response of tissue-cultured cynomolgus monkey kidney cells to botulinum C2 toxin.组织培养的食蟹猴肾细胞对肉毒杆菌C2毒素的反应。
Microb Pathog. 1987 Oct;3(4):279-86. doi: 10.1016/0882-4010(87)90061-1.
10
ADP-ribosylation of nonmuscle actin by component I of botulinum C2 toxin inactivates the ability to interact with unmodified actin.
J Biochem. 1990 Mar;107(3):420-5. doi: 10.1093/oxfordjournals.jbchem.a123060.