Gahr M, Jentsch E, Schröter W
Acta Haematol. 1976;56(1):39-46. doi: 10.1159/000207917.
Haemoglobin fractions and 16 enzymatic activities of red cells of a patient with juvenile chronic myeloid leukaemia are compared to normal, to comparably reticulocyte-rich, non-neonatal and to fetal red cells. The activities of hexokinase, triosephosphate isomerase, glyceraldehyde-3-phosphate dehydrogenase, monophosphoglyceromutase, enolase and glucose-6-phosphate dehydrogenase are significantly increased in fetal red cells beyond the activities of cell populations with comparable reticulocytosis. The activities of these enzymes are also increased in the patient's erythrocytes. Together with a haemoglobin F concentration of 54% and a concentration of haemoglobin Bart's of 1% these variations reflect the fetal nature of the red cells. Simultaneously, signs of dyserythropoiesis are found in the red cells of the patient: a very high activity of hexokinase and a low pyruvate kinase activity.
将一名青少年慢性髓性白血病患者红细胞的血红蛋白组分和16种酶活性与正常红细胞、网织红细胞丰富程度相当的非新生儿红细胞以及胎儿红细胞进行比较。与网织红细胞增多程度相当的细胞群体相比，胎儿红细胞中己糖激酶、磷酸丙糖异构酶、甘油醛-3-磷酸脱氢酶、单磷酸甘油酸变位酶、烯醇化酶和葡萄糖-6-磷酸脱氢酶的活性显著增加。这些酶的活性在患者红细胞中也有所增加。连同54%的血红蛋白F浓度和1%的血红蛋白Bart浓度，这些变化反映了红细胞的胎儿特性。同时，在患者红细胞中发现了红细胞生成异常的迹象：己糖激酶活性非常高，丙酮酸激酶活性低。
