Hinchliffe R F
Section of Paediatric Haematology, University of Sheffield.
J Clin Pathol. 1993 Sep;46(9):878-9. doi: 10.1136/jcp.46.9.878.
Serial reticulocyte counts on a patient with an unstable haemoglobin haemolytic anaemia whose red cells contained Heinz bodies were obtained by two automated methods. One false low and several false high counts were obtained with standard threshold settings; each was accompanied by activation of the appropriate alarm. With the FACScan a bimodal red cell distribution was found, corresponding to the proportions of Heinz body positive and negative cells. This case illustrates the fact that Heinz bodies can interfere with automated reticulocyte counting methods, and to a degree that could be clinically important.
通过两种自动化方法对一名患有不稳定血红蛋白溶血性贫血且红细胞含有海因茨小体的患者进行连续网织红细胞计数。在标准阈值设置下获得了一次假低计数和几次假高计数；每次都伴有相应警报的激活。使用FACScan发现了双峰红细胞分布，这与海因茨小体阳性和阴性细胞的比例相对应。该病例表明海因茨小体可干扰自动化网织红细胞计数方法，且干扰程度在临床上可能具有重要意义。
