Ortel B, Perl S, Kinaciyan T, Calzavara-Pinton P G, Hönigsmann H
Department of Dermatology, University of Vienna, School of Medicine, Austria.
J Am Acad Dermatol. 1993 Nov;29(5 Pt 1):736-40. doi: 10.1016/0190-9622(93)70239-p.
There is a disparity between the absorption spectrum of 8-methoxypsoralen and the action spectrum for psoralen-sensitized erythema. In an action spectrum corrected for unsensitized reaction 313 and 365 nm have similar efficacies.
We evaluated the relative erythemogenic and antipsoriatic efficacy of narrow-band (311 nm) UVB with and without prior psoralen exposure. We also compared the effects of narrow-band UVB and broad-band UVA after oral and bath-water psoralen exposure.
Patients with psoriasis underwent half-side comparison studies. In one group the therapeutic efficacy of 311 nm UVB with and without oral psoralen was assessed. The second group received UVA and 311 nm UVB after oral psoralen. The third group was exposed to both radiation sources after bath-water exposure.
The erythemogenic, pigmentogenic, and therapeutic efficacy of 311 nm was increased by oral psoralen. With systemic 8-methoxypsoralen, UVA was comparable to 311 nm UVB. After bath-water exposure, 311 nm was clearly superior to broad-band UVA.
The efficacy of narrow-band 311 nm UVB can be enhanced by psoralen. Narrow-band 311 nm UVB is also effective after psoralen bath-water delivery.
8-甲氧基补骨脂素的吸收光谱与补骨脂素致敏性红斑的作用光谱之间存在差异。在针对非致敏反应校正的作用光谱中，313和365纳米具有相似的疗效。
我们评估了窄谱（311纳米）紫外线B（UVB）在有或无补骨脂素预先暴露情况下的相对致红斑和抗银屑病疗效。我们还比较了口服和浴水补骨脂素暴露后窄谱UVB和宽谱紫外线A（UVA）的效果。
银屑病患者进行半侧比较研究。一组评估了311纳米UVB在有或无口服补骨脂素情况下的治疗效果。第二组在口服补骨脂素后接受UVA和311纳米UVB。第三组在浴水暴露后接受两种辐射源照射。
口服补骨脂素可提高311纳米的致红斑、色素沉着和治疗效果。使用全身性8-甲氧基补骨脂素时，UVA与311纳米UVB相当。浴水暴露后，311纳米明显优于宽谱UVA。
补骨脂素可增强窄谱311纳米UVB的疗效。补骨脂素浴水给药后，窄谱311纳米UVB也有效。
