Cohen D, Eisdorfer C, Gorelick P, Paveza G, Luchins D J, Freels S, Ashford J W, Semla T, Levy P, Hirschman R
Department of Aging and Mental Health, University of South Florida, Tampa.
J Gerontol. 1993 Nov;48(6):M255-60. doi: 10.1093/geronj/48.6.m255.
This study compared the occurrence of psychiatric symptoms in a large group of community-residing participants enrolled in an Alzheimer's disease patient registry who met clinical diagnostic criteria for Alzheimer's disease or multi-infarct dementia, as well as mixed Alzheimer's disease and multi-infarct dementia.
Psychiatric morbidity observed from a psychiatric examination of 514 patients with Alzheimer's disease, 135 patients with multi-infarct dementia, and 86 cases with mixed dementia was analyzed using analysis of variance comparing symptoms across groups and chi-square test for differences in frequency of occurrence. Associations between pairs of symptoms were also reported.
The frequency of occurrence and patterns of psychiatric problems were similar in patients with Alzheimer's disease and multi-infarct dementia. Agitation was the most frequent symptom, followed by depression, apathy, and behavioral disorders. Patients with mixed dementia had significantly more psychopathology.
This study demonstrated that significant psychopathology occurs in individuals with Alzheimer's disease or multi-infarct dementia. The high levels of symptoms in mixed dementia suggest that the two conditions have a synergistic effect on behavioral problems. The prevalence of multiple symptoms is higher than previously reported.
本研究比较了一大群登记在阿尔茨海默病患者登记处的社区居住参与者中精神症状的发生率，这些参与者符合阿尔茨海默病或多发性梗死性痴呆的临床诊断标准，以及混合性阿尔茨海默病和多发性梗死性痴呆。
对514例阿尔茨海默病患者、135例多发性梗死性痴呆患者和86例混合性痴呆患者进行精神检查，观察到的精神疾病发病率采用方差分析比较各组症状，并采用卡方检验分析发生率差异。还报告了症状对之间的关联。
阿尔茨海默病患者和多发性梗死性痴呆患者的精神问题发生率和模式相似。激越为最常见症状，其次是抑郁、淡漠和行为障碍。混合性痴呆患者的精神病理学问题明显更多。
本研究表明，阿尔茨海默病或多发性梗死性痴呆患者存在明显的精神病理学问题。混合性痴呆中症状水平较高表明这两种情况对行为问题有协同作用。多种症状的患病率高于先前报道。
