Marpeau L, Jault T, Gauchet F, Barrat J, Milliez J
Service de Gynécologie Obstétrique, Hôpital Saint-Antoine, Paris.
J Gynecol Obstet Biol Reprod (Paris). 1993;22(5):539-42.
To study the impact of 0.25% bupivacaine on the frequency and intensity of uterine contractions.
52 patients in labour. Continuous internal tokographic measurement of uterine activity at 10 minutes before instilling the bupivacaine and at 30 minutes after doing so. The true frequency and intensity of the uterine contractions were the two parameters that were studied.
There was a significant variation (matched Student's test) between the two parameters that were studied: there was transitory hypokinesia (p = 0.003) and intense prolonged hyperkinesia (p < 0.001).
0.25% bupivacaine produces hyperkinetic increases in intensity of the contractions of which the mechanism has not been elucidated; therefore it is inadvisable to add oxytocics in the minutes after instilling bupivacaine.
研究0.25%布比卡因对子宫收缩频率和强度的影响。
52例分娩患者。在注入布比卡因前10分钟及注入后30分钟连续进行子宫活动的内部宫缩图测量。所研究的两个参数为子宫收缩的实际频率和强度。
所研究的两个参数之间存在显著差异（配对学生检验）：出现短暂性运动功能减退（p = 0.003）和强烈的持续性运动功能亢进（p < 0.001）。
0.25%布比卡因会使宫缩强度出现运动功能亢进性增加，其机制尚未阐明；因此，在注入布比卡因后的几分钟内不宜加用催产剂。
