Cooper R A, Devlin E, Boyd T H, Bali I M
Department of Anaesthetics, Queen's University, Belfast, Northern Ireland.
Eur J Anaesthesiol. 1993 May;10(3):183-7.
Seventy women who requested epidural pain relief in labour received a continuous epidural infusion at 8 ml h-1, which contained either 0.25% bupivacaine (n = 29), or a mixture of 0.125% bupivacaine and 0.005% alfentanil (n = 31), assigned randomly. Increments of 4 ml 0.25% bupivacaine were given on demand to prevent residual pain from uterine contractions. The two groups were compared for motor block of the lower limbs, number of increments required, type of delivery and neonatal Apgar scores. The group of women receiving the mixture of bupivacaine and alfentanil required between them seven increments; the group receiving bupivacaine alone required 15. One of the women receiving the mixture and eight of the women receiving bupivacaine alone had almost complete motor block. There were no differences in the mode of delivery or in the neonatal Apgar scores.
70名要求分娩时硬膜外镇痛的女性接受了8毫升/小时的持续硬膜外输注，随机分为两组，一组输注含0.25%布比卡因的溶液（n = 29），另一组输注含0.125%布比卡因和0.005%阿芬太尼的混合溶液（n = 31）。根据需要追加4毫升0.25%布比卡因，以防止子宫收缩引起的残留疼痛。比较两组下肢运动阻滞情况、所需追加次数、分娩方式及新生儿阿普加评分。接受布比卡因和阿芬太尼混合溶液的女性组共需要7次追加；单独接受布比卡因的组需要15次。接受混合溶液的女性中有1例、单独接受布比卡因的女性中有8例出现几乎完全的运动阻滞。两组在分娩方式或新生儿阿普加评分方面无差异。
