Schuitemaker H, Meyaard L, Kootstra N A, Dubbes R, Otto S A, Tersmette M, Heeney J L, Miedema F
Department of Clinical Viro-Immunology, Central Laboratory of The Netherlands Red Cross Blood Transfusion Service, Amsterdam.
J Infect Dis. 1993 Nov;168(5):1140-7. doi: 10.1093/infdis/168.5.1140.
In asymptomatic human immunodeficiency virus (HIV) infection in humans, disturbed T cell functions such as anergy and programmed cell death, thought to result from inappropriate signaling by antigen-presenting cells due to HIV infection, precede increase in virus load, decline in CD4+ T cell numbers, and subsequent disease progression. Here, in 3 long-term HIV-1-infected asymptomatic chimpanzees, antigen-presenting cell function was intact and T cells had normal proliferative capacity with no evidence of HIV-1-associated programmed cell death. Polymerase chain reaction analysis demonstrated low frequencies of cells harboring proviral DNA. Primary virus isolation from the infected animals demonstrated the absence of monocytotropic HIV-1 variants, in concordance with complete insusceptibility of chimpanzee monocytes for HIV-1 infection. Possibly, because of the incapacity of HIV-1 to infect monocytes, systemic immune dysfunction will not occur, contributing to controlled viral replication and maintenance of the asymptomatic state in HIV-infected chimpanzees.
在人类无症状性人类免疫缺陷病毒（HIV）感染中，T细胞功能紊乱，如无反应性和程序性细胞死亡，被认为是由于HIV感染导致抗原呈递细胞信号传导不当所致，这些功能紊乱先于病毒载量增加、CD4+T细胞数量下降以及随后的疾病进展。在此，在3只长期感染HIV-1的无症状黑猩猩中，抗原呈递细胞功能完好，T细胞具有正常的增殖能力，且没有HIV-1相关程序性细胞死亡的证据。聚合酶链反应分析显示，携带前病毒DNA的细胞频率较低。从受感染动物中进行的原发性病毒分离表明，不存在嗜单核细胞性HIV-1变体，这与黑猩猩单核细胞对HIV-1感染完全不敏感相一致。可能由于HIV-1无法感染单核细胞，所以不会发生全身性免疫功能障碍，这有助于控制病毒复制并维持HIV感染黑猩猩的无症状状态。
