Makhoul I R, Merzbach D, Lichtig C, Berant M
Dept. of Neonatology, Rambam Medical Center, Haifa, Israel.
J Infect Dis. 1993 Nov;168(5):1296-9. doi: 10.1093/infdis/168.5.1296.
Pseudomonas aeruginosa pneumonia is associated with high mortality despite appropriate systemic antibacterial therapy. To examine the effects of aerosolized tobramycin on experimental P. aeruginosa pneumonia, guinea pigs were assigned to two main groups: a study group, in which P. aeruginosa was instilled into the tracheal lumen, and a control group, in which normal saline was instilled. Each group was then subdivided according to treatment: normal saline or tobramycin by intramuscular injection, normal saline or tobramycin by aerosol, or normal saline or tobramycin via both aerosol and intramuscular injection. Compared with either intramuscular or aerosolized tobramycin, the combination of aerosol plus intramuscular tobramycin achieved slightly higher survival, total eradication of P. aeruginosa from lungs, and a significant further reduction of lung inflammatory changes. Adding aerosolized tobramycin to systemic tobramycin in the treatment of experimental P. aeruginosa pneumonia enhanced eradication of P. aeruginosa and mitigated pulmonary inflammatory changes.
尽管进行了适当的全身抗菌治疗，但铜绿假单胞菌肺炎的死亡率仍然很高。为了研究雾化妥布霉素对实验性铜绿假单胞菌肺炎的影响，将豚鼠分为两个主要组：一个研究组，将铜绿假单胞菌注入气管腔内；一个对照组，注入生理盐水。然后根据治疗方法将每组再细分：通过肌肉注射给予生理盐水或妥布霉素，通过雾化给予生理盐水或妥布霉素，或通过雾化和肌肉注射两种方式给予生理盐水或妥布霉素。与单独肌肉注射或雾化妥布霉素相比，雾化加肌肉注射妥布霉素的联合治疗在生存率、肺部铜绿假单胞菌的完全清除以及肺部炎症变化的显著进一步减轻方面略高。在实验性铜绿假单胞菌肺炎的治疗中，在全身使用妥布霉素的基础上加用雾化妥布霉素可增强铜绿假单胞菌的清除并减轻肺部炎症变化。
