非人类灵长类动物的血小板和动脉组织在体内无法将预先形成的[14C]羊毛甾醇转化为[14C]胆固醇。
Non-human primate platelets and arterial tissue cannot convert preformed [14C]lanosterol into[14C]cholesterol in vivo.
作者信息
Derksen A, Meguid M M, Cohen P
出版信息
Biochem J. 1976 Jul 15;158(1):157-9. doi: 10.1042/bj1580157.
Abstract
In contrast with the prevailing view, we report the inability of non-human primate platelets or arterial tissue to complete the biosynthesis of [14C]cholesterol from [14C]mevalonic acid in vitro or in vivo, or from performed [14C]lanosterol in vivo. The latter observation suggests that these tissues lack one or more components of the methyl sterol demethylase system.
摘要
与普遍观点相反，我们报告了非人类灵长类动物的血小板或动脉组织在体外或体内无法从[14C]甲羟戊酸完成[14C]胆固醇的生物合成，在体内也无法从预先形成的[14C]羊毛甾醇完成[14C]胆固醇的生物合成。后一观察结果表明，这些组织缺乏甲基甾醇脱甲基酶系统的一种或多种成分。
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Non-human primate platelets and arterial tissue cannot convert preformed [14C]lanosterol into[14C]cholesterol in vivo.非人类灵长类动物的血小板和动脉组织在体内无法将预先形成的[14C]羊毛甾醇转化为[14C]胆固醇。
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本文引用的文献
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Proc Soc Exp Biol Med. 1958 Aug-Sep;98(4):680-3. doi: 10.3181/00379727-98-24150.
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Synthesis of squalene and sterols by isolated segments of human and pigeon arteries.人及鸽动脉离体节段合成角鲨烯和甾醇的研究
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Sterol synthesis in the human arterial intima.人体动脉内膜中的固醇合成。
J Clin Invest. 1968 Mar;47(3):595-603. doi: 10.1172/JCI105755.
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Biosynthesis of squalene and sterols by rat aorta.大鼠主动脉中角鲨烯和甾醇的生物合成
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Extensive incorporation of (2-14C) mevalonic acid into cholesterol precursors by human platelets in vitro.
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