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戊型肝炎病毒感染患者血清样本中戊型肝炎病毒IgA类抗体的检测

Detection of IgA class antibody to hepatitis E virus in serum samples from patients with hepatitis E virus infection.

作者信息

Chau K H, Dawson G J, Bile K M, Magnius L O, Sjogren M H, Mushahwar I K

机构信息

Experimental Biology Research, Abbott Laboratories, North Chicago, Illinois 60064.

出版信息

J Med Virol. 1993 Aug;40(4):334-8. doi: 10.1002/jmv.1890400414.

DOI:10.1002/jmv.1890400414
PMID:8228927
Abstract

A newly developed assay for IgA class antibody to hepatitis E virus (IgA anti-HEV) was used to study 145 serum samples collected during an outbreak of an enterically transmitted hepatitis that occurred in 3 villages in the lower Shebeli region of Southern Somalia between January, 1988 and November, 1989. A total of 52.4% of the afflicted patients were found positive for IgA anti-HEV, and 73.1% of these were also positive for IgM. Both antibodies disappeared during the convalescence period. Similar results were also seen in serum obtained from sporadic cases of acute waterborne hepatitis in Pakistan.

摘要

一种新开发的检测戊型肝炎病毒IgA类抗体(IgA抗-HEV)的方法,被用于研究1988年1月至1989年11月间在索马里南部谢贝利河下游地区3个村庄发生的一次经肠道传播的肝炎暴发期间采集的145份血清样本。总共52.4%的患病患者被检测出IgA抗-HEV呈阳性,其中73.1%的患者IgM也呈阳性。两种抗体在恢复期均消失。在从巴基斯坦急性水源性肝炎散发病例获得的血清中也观察到了类似结果。

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