急性戊型肝炎病毒感染患者血清IgA的意义。
Significance of serum IgA in patients with acute hepatitis E virus infection.
作者信息
Tian De-Ying, Chen Yan, Xia Ning-Shao
机构信息
Department of Infectious Diseases, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Provice, China.
出版信息
World J Gastroenterol. 2006 Jun 28;12(24):3919-23. doi: 10.3748/wjg.v12.i24.3919.
AIM
To study the significance of serum anti-hepatitis E virus (HEV) IgA in patients with hepatitis E.
METHODS
A new method was established to assay anti-HEV IgA, which could be detected in the middle phase of the infection. We compared anti-HEV IgA assay with anti-HEV IgM and anti-HEV IgG assay in sera from 60 patients with positive HEV-RNA.
RESULTS
The 60 patients with positive HEV-RNA had both anti-HEV IgA and anti-HEV IgM and 410 patients with negative HEV-RNA were used as control. Periodic serum samples obtained from 60 patients with hepatitis E were tested for HEV RNA, anti-HEV IgM, anti-HEV IgA and anti-HEV IgG. Their HEV-RNA was detectable in the serum until 20 +/- 11 d. We used anti-HEV IgM and anti-HEV IgA assay to detect HEV infection and positive results were found in 90 +/- 15 d and 120 +/- 23 d respectively, the positive rate of anti-HEV IgA was higher than that of anti-HEV IgM and HEV-RNA (P < 0.05).
CONCLUSION
The duration of anti-HEV IgA in serum is longer than that of anti-HEV IgM, and anti-HEV IgA assay is a good method to detect HEV infection.
目的
研究戊型肝炎患者血清抗戊型肝炎病毒（HEV）IgA的意义。
方法
建立一种检测抗HEV IgA的新方法，该方法可在感染中期检测到。我们将抗HEV IgA检测与抗HEV IgM和抗HEV IgG检测在60例HEV-RNA阳性患者的血清中进行比较。
结果
60例HEV-RNA阳性患者同时存在抗HEV IgA和抗HEV IgM，410例HEV-RNA阴性患者作为对照。从60例戊型肝炎患者中定期采集血清样本，检测HEV RNA、抗HEV IgM、抗HEV IgA和抗HEV IgG。他们的血清中HEV-RNA在20±11天内均可检测到。我们用抗HEV IgM和抗HEV IgA检测来检测HEV感染，分别在90±15天和120±23天发现阳性结果，抗HEV IgA的阳性率高于抗HEV IgM和HEV-RNA（P<0.05）。
结论
血清中抗HEV IgA的持续时间长于抗HEV IgM，抗HEV IgA检测是检测HEV感染的一种好方法。
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