Shen C Y, Chang S F, Chao M F, Yang S L, Lin G M, Chang W W, Wu C W, Yen M S, Ng H T, Thomas J C
Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.
J Med Virol. 1993 Sep;41(1):24-9. doi: 10.1002/jmv.1890410106.
To understand reasons for cytomegalovirus (CMV) recurrence, a cohort of 350 CMV-seropositive pregnant women attending obstetric clinics in Taiwan was examined for cervical or urinary CMV shedding. Urine specimens were collected from 350 women and cervical secretion specimens were collected from 220 women. We measured the association of various factors with CMV recurrence, which was defined as viral shedding identified by the presence of a CMV-specific gene sequence amplified by the polymerase chain reaction in seropositive individuals. CMV recurrence status was independently associated with a sexual activity composite variable, which was defined by three sexual activity indicators: age at first sexual intercourse, total years of sexual experience, and average frequency of sexual intercourse prior to pregnancy. Pregnant women with a history of genital tract infection were more likely than women without such history to experience cervical CMV recurrence. Similarly, pregnant women with previous urinary tract infections were more likely to experience urinary CMV recurrence. The findings indicate that multiple exposure to CMV by sexual activity prior to pregnancy is an important determinant of CMV recurrence during pregnancy.
为了解巨细胞病毒（CMV）复发的原因，我们对台湾地区350名在产科诊所就诊的CMV血清学阳性孕妇进行了宫颈或尿液CMV脱落检测。收集了350名女性的尿液标本和220名女性的宫颈分泌物标本。我们测量了各种因素与CMV复发的关联，CMV复发定义为在血清学阳性个体中通过聚合酶链反应扩增出CMV特异性基因序列来确定病毒脱落。CMV复发状态与一个性活动复合变量独立相关，该复合变量由三个性活动指标定义：首次性交年龄、性经历总年数以及怀孕前性交的平均频率。有生殖道感染史的孕妇比无此类病史的孕妇更易出现宫颈CMV复发。同样，既往有尿路感染的孕妇更易出现尿液CMV复发。研究结果表明，怀孕前通过性活动多次接触CMV是孕期CMV复发的一个重要决定因素。
