Lucas-Héron B, Ollivier B, Schmitt N
Laboratoire de Physiologie, U.E.R. de Médecine, Nantes, France.
J Neurol Sci. 1993 Aug;118(1):97-100. doi: 10.1016/0022-510x(93)90253-u.
The effect of torbafylline, a xanthine derivative (Hoechst, Werk Albert, Wiesbaden, Germany), was tested relative to changes in degeneration and subsequent regeneration processes in mouse gastrocnemius muscle induced by a single injection of chlorpromazine, a myotoxic drug. These processes were monitored by measuring changes in calmitine, a mitochondrial protein. We determined in our previous work that calmitine concentration decreases during degeneration and progressively increases during regeneration. In this study, we compared effects in torbafylline-treated mice with those in control mice treated with saline solution. The results show that regeneration is much faster with torbafylline treatment. Calmitine is decreased and returns quickly to normal in torbafylline-treated mice as compared to those treated with saline solution. Torbafylline might thus prove effective in stimulating muscle regeneration in myopathy.
测试了黄嘌呤衍生物托巴茶碱（德国威斯巴登市赫斯特制药公司生产）对单次注射氯丙嗪（一种肌毒性药物）诱导的小鼠腓肠肌变性及后续再生过程变化的影响。通过测量线粒体蛋白钙调素的变化来监测这些过程。我们在之前的研究中确定，钙调素浓度在变性过程中降低，在再生过程中逐渐升高。在本研究中，我们比较了托巴茶碱处理小鼠与生理盐水处理对照小鼠的效果。结果表明，托巴茶碱处理能使再生速度显著加快。与生理盐水处理的小鼠相比，托巴茶碱处理的小鼠钙调素浓度降低且能更快恢复正常。因此，托巴茶碱可能对刺激肌病中的肌肉再生有效。
