Shimakawa T, Bild D E
Division of Epidemiology and Clinical Applications, National Heart, Lung, and Blood Institute, Bethesda, MD 20892.
J Clin Epidemiol. 1993 Nov;46(11):1257-66. doi: 10.1016/0895-4356(93)90090-n.
To understand mechanisms of association between hemoglobin and cardiovascular disease (CVD), the relationships between hemoglobin and CVD risk factors were examined in 5115 black and white men and women who participated in the Coronary Artery Risk Development in Young Adults (CARDIA) Study. Hemoglobin was higher in men than women, whites than blacks, and smokers than non-smokers (p < 0.001). After adjusting for age, body mass index, current smoking status, and clinical center, hemoglobin correlated with diastolic blood pressure (0.11 < or = r < or = 0.22, p < 0.001) and plasma total cholesterol (0.08 < or = r < or = 0.11, p < 0.01) in all four race-sex groups and with systolic blood pressure in all but black women (0.07 < or = r < or = 0.13, p < 0.05). Among other factors possibly related to CVD risk, only serum albumin and white blood cell count showed significant correlations with hemoglobin in all groups (0.19 < or = r < or = 0.27, 0.07 < or = r < or = 0.18, respectively). These findings suggest that an association of hemoglobin with CVD risk factors may explain the association of hemoglobin with CVD.
为了解血红蛋白与心血管疾病（CVD）之间的关联机制，在参与青年动脉粥样硬化风险发展研究（CARDIA研究）的5115名黑人和白人男性及女性中，对血红蛋白与CVD危险因素之间的关系进行了研究。男性的血红蛋白水平高于女性，白人高于黑人，吸烟者高于非吸烟者（p<0.001）。在对年龄、体重指数、当前吸烟状况和临床中心进行校正后，在所有四个种族-性别组中，血红蛋白与舒张压相关（0.11≤r≤0.22，p<0.001），与血浆总胆固醇相关（0.08≤r≤0.11，p<0.01），在除黑人女性外的所有组中与收缩压相关（0.07≤r≤0.13，p<0.05）。在其他可能与CVD风险相关的因素中，只有血清白蛋白和白细胞计数在所有组中与血红蛋白有显著相关性（分别为0.19≤r≤0.27和0.07≤r≤0.18）。这些发现表明，血红蛋白与CVD危险因素之间的关联可能解释了血红蛋白与CVD之间的关联。
