Scaglione F, Ferrara F, Dugnani S, Demartini G, Triscari F, Fraschini F
Dept. Pharmacology, University of Milan, Italy.
J Chemother. 1993 Aug;5(4):228-32. doi: 10.1080/1120009x.1993.11739237.
The immune response to infecting pathogens may be either enhanced or depressed by therapeutic antimicrobial agents. Some macrolides have been shown to enhance aspects of the immune response. This study evaluates the effects of clarithromycin, a new broad-spectrum macrolide antibiotic, on leukocyte function in both healthy volunteers (single 500 mg dose) and chronic bronchitis patients (500 mg b.i.d.) by testing blood samples collected at baseline and at 2, 4, 8 and 12 hours after clarithromycin administration. Clarithromycin did not affect leukocyte chemotaxis but did significantly increase (P < 0.01) phagocytosis (both frequency and index), intracellular killing and natural killer activity, in healthy volunteers. In patients, clarithromycin enhanced phagocytosis frequency, index and intracellular killing. Clarithromycin appears to enhance the human immune response; the mechanism, pharmacodynamics, and clinical significance of this enhancement remain unknown.
治疗性抗菌药物可能会增强或抑制机体对感染病原体的免疫反应。一些大环内酯类药物已被证明可增强免疫反应的某些方面。本研究通过检测在基线以及服用克拉霉素后2、4、8和12小时采集的血样，评估新型广谱大环内酯类抗生素克拉霉素对健康志愿者（单次500mg剂量）和慢性支气管炎患者（500mg，每日两次）白细胞功能的影响。克拉霉素不影响白细胞趋化性，但在健康志愿者中显著增加了吞噬作用（频率和指数）、细胞内杀菌作用和自然杀伤活性（P<0.01）。在患者中，克拉霉素增强了吞噬作用的频率、指数和细胞内杀菌作用。克拉霉素似乎可增强人体免疫反应；这种增强作用的机制、药效学和临床意义尚不清楚。
