Greer J R, Abbey D E, Burchette R J
Department of Preventive Medicine, School of Public Health, Loma Linda University, California 92350.
J Occup Med. 1993 Sep;35(9):909-15. doi: 10.1097/00043764-199309000-00014.
We attempted to determine the association between occupational and air pollutant exposure with the development of adult asthma through the analysis of a standardized respiratory questionnaire administered to a cohort of 3914 nonsmoking adults in 1977 and again in 1987. Ambient air pollution concentrations were estimated over a 20-year period using monthly interpolations from fixed-site monitoring stations applied to zip code locations by month of residence and work site. Second-hand smoke exposure was significantly associated with the development of asthma (related risk [RR] = 1.45, confidence interval [CI] = 1.21 to 1.75). Airways obstructive disease before age 16 was related to a marked increased risk (RR = 4.24, CI = 4.03 to 4.45). An increased risk of asthma was significantly associated with increased ambient concentrations of ozone exposure in men (RR = 3.12, CI = 1.61 to 5.85).
我们试图通过对1977年和1987年分别向3914名不吸烟成年人队列进行的标准化呼吸问卷分析，来确定职业暴露和空气污染物暴露与成人哮喘发病之间的关联。利用固定站点监测站的月度插值数据，根据居住和工作地点的邮政编码，对20年期间的环境空气污染浓度进行了估算。二手烟暴露与哮喘发病显著相关（相对风险[RR]=1.45，置信区间[CI]=1.21至1.75）。16岁之前的气道阻塞性疾病与显著增加的风险相关（RR=4.24，CI=4.03至4.45）。男性哮喘风险增加与环境中臭氧暴露浓度增加显著相关（RR=3.12，CI=1.61至5.85）。
