Salisbury J R, Deverell M H, Cookson M J, Whimster W F
Department of Histopathology, King's College School of Medicine and Dentistry, London, U.K.
J Pathol. 1993 Sep;171(1):59-62. doi: 10.1002/path.1711710112.
Three-dimensional reconstruction experiments performed on serial sections of human embryos showed that the anatomy of the caudal and rostral ends of the notochord was complex. Forking of the ends, with separate fragments of chordal tissue, was demonstrated and these provide a way by which notochordal cell rests could be left behind in the basicranial and sacral regions when the notochord involutes elsewhere. Assuming the histogenesis of chordomas from notochordal cell rests, this would furnish an explanation for the observed skeletal distribution of chordomas.
对人类胚胎连续切片进行的三维重建实验表明，脊索尾端和头端的解剖结构很复杂。已证实脊索末端存在分叉，伴有单独的脊索组织碎片，当脊索在其他部位退化时，这些分叉和碎片为脊索细胞残余留在颅底和骶骨区域提供了一种方式。假设脊索瘤起源于脊索细胞残余，这将为观察到的脊索瘤骨骼分布提供一个解释。
