Ditto B, Edwards M C, Miller S, D'Antono B, Blum S
Department of Psychology, McGill University, Montreal, Quebec, Canada.
J Psychosom Res. 1993 Oct;37(7):771-80. doi: 10.1016/0022-3999(93)90106-p.
Two cold pressor tests were administered to 18 healthy normotensive males on two occasions, after 2 weeks of dietary sodium loading and after 2 weeks of maintaining their normal diet. While the addition of an extra 10 g/day of sodium to the diet had no overall effect on resting cardiovascular activity, it produced significantly greater diastolic blood pressure and smaller heart rate responses to the pain stimuli. As well, consistent with the large animal literature indicating a relationship between high blood pressure and diminished pain sensitivity, pain ratings were found to be significantly lower during the sodium loaded testing session. The ratings were corroborated by evidence of lower skin conductance reactivity to the second cold pressor test in the sodium loaded condition. Information concerning an elevation of risk for hypertension, perhaps provided by baroreceptors, may lead to compensatory reactions with hypoalgesia as one effect.
对18名健康的血压正常男性进行了两次冷加压试验，分别在饮食中钠负荷2周后和维持正常饮食2周后进行。虽然每天额外增加10克钠的饮食对静息心血管活动没有总体影响，但它对疼痛刺激产生了显著更高的舒张压和更小的心率反应。此外，与大量动物文献表明高血压与疼痛敏感性降低之间存在关系一致，发现在钠负荷测试期间疼痛评分显著更低。钠负荷状态下对第二次冷加压试验皮肤电导反应性降低的证据证实了这些评分。关于高血压风险升高的信息，可能由压力感受器提供，可能会导致以痛觉减退为一种效应的代偿反应。
