Rosa C, Ghione S, Mezzasalma L, Pellegrini M, Basile Fasolo C, Giaconi S, Gazzetti P, Ferdeghini M
CNR, Istitute of Clinical Physiology, University of Pisa, Italy.
Clin Exp Hypertens A. 1988;10 Suppl 1:383-90. doi: 10.3109/10641968809075994.
An association between increased blood pressure levels and hypoalgesia has been reported in the experimental animal and in man. The relation between pain perception and cardiovascular function is however still obscure. In order to gain some insight into this aspect, normotensive subjects with low and high tolerance to pain, as assessed by tooth pulp stimulation, were compared for blood pressure and heart rate during cold pressor test, 24 hr urinary catecholamines, supine and upright PRA and plasma beta-endorphin levels. No significant difference was observed between the two groups for casual blood pressure, heart rate and PRA. Compared to subjects with low tolerance to pain, those with high tolerance to pain were significantly older and had: 1) significantly higher levels of diastolic blood pressure and of beta endorphin levels during cold pressor test; 2) significantly higher beta-endorphin levels after cold pressor test; 3) a significantly higher excretion of noradrenaline (but not of adrenaline and dopamine).
在实验动物和人类中，均有血压水平升高与痛觉减退之间存在关联的报道。然而，疼痛感知与心血管功能之间的关系仍不明确。为了深入了解这一方面，通过牙髓刺激评估的对疼痛低耐受性和高耐受性的血压正常受试者，在冷加压试验期间比较了血压和心率、24小时尿儿茶酚胺、仰卧位和直立位的肾素活性（PRA）以及血浆β-内啡肽水平。两组在随机血压、心率和PRA方面未观察到显著差异。与对疼痛低耐受性的受试者相比，对疼痛高耐受性的受试者年龄显著更大，并且有：1）在冷加压试验期间舒张压水平和β-内啡肽水平显著更高；2）冷加压试验后β-内啡肽水平显著更高；3）去甲肾上腺素排泄显著更高（但肾上腺素和多巴胺排泄无显著差异）。
