Hellmén E
Department of Pathology, Swedish University of Agricultural Sciences, Faculty of Veterinary Medicine, Uppsala.
J Reprod Fertil Suppl. 1993;47:489-99.
Mammary tumours are the most common tumours in the female dog. The tumours have a complex histology and exist in epithelial, mixed and mesenchymal forms. To study the biology of canine mammary tumours, five cell lines have been established and characterized. The results indicate that canine mammary tumours might be derived from mammary stem cells and that the tumour growth is independent of oestrogens. The established canine mammary tumour cell lines will be valuable tools in further studies of the histogenesis and pathogenesis of these tumours.
乳腺肿瘤是雌性犬类中最常见的肿瘤。这些肿瘤具有复杂的组织学结构，存在上皮、混合和间充质三种形式。为了研究犬乳腺肿瘤的生物学特性，已建立并鉴定了五种细胞系。结果表明，犬乳腺肿瘤可能起源于乳腺干细胞，且肿瘤生长独立于雌激素。已建立的犬乳腺肿瘤细胞系将成为进一步研究这些肿瘤组织发生和发病机制的宝贵工具。
