Meeks G R, Whitworth N S, Renfroe M S
Department of Obstetrics and Gynecology, University of Mississippi Medical Center, Jackson.
J Miss State Med Assoc. 1993 Aug;34(8):263-6.
Androgen insensitivity syndrome (testicular feminization) is classically diagnosed by history, physical examination, karyotype and ultimately exploratory laparotomy. In this case, the diagnosis was verified by amenorrhea, female phenotype, Barr body negative buccal smear, and finally, exploratory laparotomy which revealed bilateral abdominal testes. Testicular vein blood samples obtained at the time of surgery were analyzed for testosterone, follicle stimulating hormone, luteinizing hormone, and prolactin and compared to peripheral vein blood samples. The testosterone concentration in the testicular vein was twice the concentration in the peripheral sample, reflecting gonadal function. The other testicular vein hormone concentrations mirrored the peripheral vein concentrations.
雄激素不敏感综合征（睾丸女性化）传统上通过病史、体格检查、染色体核型分析以及最终的剖腹探查来诊断。在该病例中，闭经、女性表型、口腔涂片巴氏小体阴性，最终剖腹探查发现双侧腹腔睾丸，从而证实了诊断。手术时采集的睾丸静脉血样本进行了睾酮、促卵泡激素、促黄体生成素和催乳素分析，并与外周静脉血样本进行比较。睾丸静脉中的睾酮浓度是外周样本浓度的两倍，反映了性腺功能。其他睾丸静脉激素浓度与外周静脉浓度相似。
