Iacono F, Barra S, De Rosa G, Boscaino A, Lotti T
Department of Urology, II School of Medicine, University of Naples, Italy.
J Urol. 1993 Dec;150(6):1806-9. doi: 10.1016/s0022-5347(17)35901-3.
Peyronie's disease, the etiology of which remains unknown, is characterized by a focal or multifocal disorder of penile tunica albuginea. An excessive collagen deposition gives rise to the formation of the plaque, which is fibrotic first and then becomes calcific. Typical symptoms of the disease are painful erection, pathological bending of the erect penis and impotence at the more advanced stages (43% of the cases). There is evidence that the tunica albuginea has a fundamental role in the erection mechanism. We evaluated the tunica albuginea of patients suffering from Peyronie's disease, with or without impotence, and found progressive disorders of the microstructure in areas that were not affected by fibrocalcific formations. There was a significant decrease (p < 0.0001) of elastic fiber concentration (55.05 +/- 23.83 per high power field) in patients with Peyronie's disease compared to the concentration in the tunica albuginea of a control group (128.50 +/- 11.79 per high power field). Moreover, when the elastic fiber concentration in the tunica albuginea of patients Peyronie's disease and normal erection (71.36 +/- 12.00 per high power field) was compared to the concentration in the tunica albuginea of those with Peyronie's disease and impotence (33.14 +/- 4.84 per high power field) a significant difference was noted (p < 0.0001).
佩罗尼氏病的病因尚不清楚，其特征是阴茎白膜出现局灶性或多灶性病变。胶原蛋白过度沉积导致斑块形成，斑块首先纤维化，然后钙化。该病的典型症状是勃起疼痛、勃起阴茎病理性弯曲以及在疾病晚期出现阳痿（43%的病例）。有证据表明，白膜在勃起机制中起重要作用。我们评估了患有佩罗尼氏病的患者的白膜，无论有无阳痿，并在未受纤维钙化形成影响的区域发现了微观结构的渐进性紊乱。与对照组白膜中的浓度（每高倍视野128.50 +/- 11.79）相比，佩罗尼氏病患者的弹性纤维浓度（每高倍视野55.05 +/- 23.83）显著降低（p < 0.0001）。此外，将患有佩罗尼氏病且勃起正常的患者白膜中的弹性纤维浓度（每高倍视野71.36 +/- 12.00）与患有佩罗尼氏病且阳痿的患者白膜中的浓度（每高倍视野33.14 +/- 4.84）进行比较时，发现有显著差异（p < 0.0001）。
