Structural alterations in the tunica albuginea of the penis: impact of Peyronie's disease, ageing and impotence.
作者信息
Akkus E, Carrier S, Baba K, Hsu G L, Padma-Nathan H, Nunes L, Lue T F
机构信息
Department of Urology, University of California School of Medicine, San Francisco, USA.
出版信息
Br J Urol. 1997 Jan;79(1):47-53. doi: 10.1046/j.1464-410x.1997.26511.x.
OBJECTIVE
To investigate whether changes in the structure of the tunica albuginea influence the development of erectile dysfunction.
PATIENTS AND METHODS
Biopsy specimens taken from the tunica of 64 patients (both potent and impotent) with and without Peyronie's disease were evaluated. Tissue samples were stained and examined under light and electron microscopy, and the concentration of elastic fibres present in each was measured using computerized image analysis.
RESULTS
The concentration of elastic fibres was lower in impotent than in potent patients (P = 0.0365) and was also significantly less in patients with Peyronie's disease. Furthermore, the concentration of elastic fibres decreased with age. Electron and light microscopy revealed the presence of distinct alterations in the tunica albuginea in impotent patients and patients with Peyronie's disease that might interfere with function.
CONCLUSION
The decrease in elastic fibre concentration and changes in microscopic features may contribute to erectile dysfunction by impairing the veno-occlusive function of the tunica albuginea.
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