Clegg M T, Kidwell J F, Kidwell M G, Daniel N J
Genetics. 1976 Aug;83(4):793-810. doi: 10.1093/genetics/83.4.793.
The dynamical behavior of chromosomal segments undergoing strong selection was investigated in four replicate populations of Drosophila melanogaster. This was accomplished by following the joint behavior of allozyme markers at the loci phosphoglucomutase and esterase C, adjacent to the recessive lethal locus Glued, during and following the course of selection against Glued. The results show strong selection at other loci in the region of the marked segment. Examination of the joint dynamic of the two markers indicates that there must be more than one, and probably several, selected loci in the region under observation, with large epistatic effects. The mode of selection on the segment often results in excess heterozygosity at the markers, but does not appear to be constant in time. It is concluded that the density of selective effects in the region under study is substantial.
在四个黑腹果蝇重复种群中，研究了经历强选择的染色体片段的动态行为。这是通过追踪与隐性致死基因Glued相邻的磷酸葡萄糖变位酶和酯酶C位点的等位酶标记在针对Glued的选择过程中和之后的联合行为来实现的。结果表明，在标记片段区域的其他位点存在强选择。对这两个标记的联合动态分析表明，在观察区域内必定存在不止一个，可能有几个被选择的位点，且具有较大的上位效应。对该片段的选择模式常常导致标记处杂合度过高，但似乎在时间上并不恒定。得出的结论是，研究区域内选择效应的密度很大。
