Matsuda S, Saitoh Y, Kanbayashi H, Tanaka T, Sakuma H, Maruyama Y, Ohno R
Center for Hematopoietic Disorders, Ohta Nishinouchi Hospital.
Rinsho Ketsueki. 1993 Sep;34(9):1033-8.
A 46-year-old woman with acute promyelocytic leukemia (APL) was treated with all-trans retinoic acid (ATRA) and chemotherapy according to the AML-92, M3 regimen of the Japan Adult Leukemia Study Group (JALSG). Between days 7 and 18 of therapy, she suffered chest discomfort, fever, cough, dyspnea and general fatigue. A chest roentogenogram showed bilateral interstitial infiltrates. Her leukocyte count began to increase rapidly to 6,400/microliters on day 14. Marked hypoxia (PO2 35.9 mmHg) suggested occurrence of retinoic acid (RA) syndrome. She underwent endotracheal intubation and mechanical ventilation with administration of methyl-prednisolone (m-PSL) pulse therapy. Her symptoms promptly abated. Therapy with ATRA was continued and her leukocyte count reached 44,800/microliters on day 19 of therapy. She achieved complete remission on day 48.
一名46岁的急性早幼粒细胞白血病（APL）女性患者，按照日本成人白血病研究组（JALSG）的AML-92、M3方案，接受了全反式维甲酸（ATRA）和化疗。在治疗的第7天至第18天期间，她出现了胸部不适、发热、咳嗽、呼吸困难和全身乏力。胸部X线片显示双侧间质性浸润。她的白细胞计数在第14天开始迅速增加至6400/微升。明显的低氧血症（PO2 35.9 mmHg）提示维甲酸（RA）综合征的发生。她接受了气管插管和机械通气，并给予甲泼尼龙（m-PSL）冲击治疗。她的症状迅速缓解。继续使用ATRA治疗，在治疗的第19天，她的白细胞计数达到44800/微升。她在第48天实现了完全缓解。
