Mehra N, Bhasin V K
Department of Zoology, University of Delhi, India.
Jpn J Med Sci Biol. 1993 Feb;46(1):37-43. doi: 10.7883/yoken1952.46.37.
Artemisinin and six of its derivatives were evaluated for their in vitro gametocytocidal and erythrocytic schizontocidal properties on an Indian isolate of Plasmodium falciparum. One of the metabolic derivatives, DADF-dihydroartemisinin (NIH02), was found to possess gametocytocidal and erythrocytic schizontocidal properties similar to those of artemisinin. Gametocytes of this isolate were highly susceptible to the toxic effect of NIH02 (IC50 = 6.6 ng/ml) and younger stages were more sensitive. This is the first report about the in vitro gametocytocidal properties of a derivative of artemisinin.
对青蒿素及其六种衍生物进行了评估，研究它们对一株印度恶性疟原虫分离株的体外杀配子体和红细胞内裂殖体特性。发现其中一种代谢衍生物，DADF-二氢青蒿素（NIH02）具有与青蒿素相似的杀配子体和红细胞内裂殖体特性。该分离株的配子体对NIH02的毒性作用高度敏感（IC50 = 6.6纳克/毫升），较年轻阶段更敏感。这是关于青蒿素衍生物体外杀配子体特性的首次报道。
