Kumar N, Zheng H
Department of Immunology and Infectious Diseases, Johns Hopkins University, School of Hygiene and Public Health, Baltimore, MD 21205.
Parasitol Res. 1990;76(3):214-8. doi: 10.1007/BF00930817.
Qinghaosu, an anti-malaria drug, has been found to kill not only asexual blood stages but also the early stages of gametocytes of Plasmodium falciparum. The effect of qinghaosu in vitro depends on the concentration of the drug as well as on the initial parasitemia level (IC50 = 10-20 nM with 1% initial parasitemia). Resistance of P. falciparum to other anti-malaria drugs, e.g., chloroquine and pyrimethamine, did not affect susceptibility of its asexual and sexual stages to qinghaosu. Gametocytocidal effect of qinghaosu may play a role in the interruption of malaria transmission.
青蒿素是一种抗疟疾药物，已发现它不仅能杀死恶性疟原虫的无性血液阶段，还能杀死配子体的早期阶段。青蒿素在体外的作用取决于药物浓度以及初始寄生虫血症水平（初始寄生虫血症为1%时，IC50 = 10 - 20 nM）。恶性疟原虫对其他抗疟疾药物（如氯喹和乙胺嘧啶）的耐药性并不影响其无性和有性阶段对青蒿素的敏感性。青蒿素的杀配子体作用可能在疟疾传播阻断中发挥作用。
