Schook L B, Carrick L, Berk R S
Infect Immun. 1976 Aug;14(2):564-70. doi: 10.1128/iai.14.2.564-570.1976.
Peroral administration of viable Pseudomonas aeruginosa into the stomach of mice resulted in an acute systemic infection, with death occurring within 72 h. One strain, ATCC 19660, a non-encapsulated form of P. aeruginosa, had a median lethal dose of 5.3 X 10(6) colony-forming units, whereas two encapsulated strains, ATCC 17933 and 17934, had median lethal dose values of 5.0 x 10(7) and 5.6 x 10(7) colony-forming units, respectively. Each strain required fewer organisms to establish a lethal infection via the stomach than by intravenous or intraperitoneal routes. The non-encapsulated strain, ATCC 19660, did not cause any diarrhea in the infected animals, whereas the two encapsulated strains, although less virulent, caused diarrhea when administered perorally. No signs of necrosis were noted within the gastrointestinal tract; however, hematogenous spread of the organism resulted in a vasculitis associated with the pulmonary vessels and bacterial invasion of the renal tissues. Treatment of animals with antineoplastic drugs 24 h before or simultaneously with peroral challenge resulted in an increased susceptibility to infection.
经口将活的铜绿假单胞菌接种到小鼠胃内会导致急性全身感染，72小时内会死亡。其中一个菌株ATCC 19660，是一种无荚膜的铜绿假单胞菌，其半数致死剂量为5.3×10⁶菌落形成单位，而两个有荚膜的菌株ATCC 17933和17934，半数致死剂量值分别为5.0×10⁷和5.6×10⁷菌落形成单位。与静脉注射或腹腔注射途径相比，每种菌株经胃建立致死性感染所需的菌量更少。无荚膜菌株ATCC 19660在感染动物中未引起任何腹泻，而两个有荚膜的菌株虽然毒力较弱，但经口给药时会引起腹泻。胃肠道内未观察到坏死迹象；然而，该菌的血行播散导致了与肺血管相关的血管炎以及细菌对肾组织的侵袭。在经口攻击前24小时或同时用抗肿瘤药物治疗动物会导致其对感染的易感性增加。
