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基因表达:来自III类的惊喜。

Gene expression: surprises from the class III side.

作者信息

Shastry B S

机构信息

Eye Research Institute, Oakland University, Rochester, MI 48309.

出版信息

Mol Cell Biochem. 1993 Jul 7;124(1):85-9. doi: 10.1007/BF01096385.

Abstract

Those genes which are transcribed by RNA polymerase III continue to give surprising results with respect to their cis-acting elements and transacting factors. As a result, a broader view of class III promoters has emerged and the internal promoters are not universal in classical polymerase III genes. The involvement of TFIID, TFIIA, a factor homologous to TFIIB and an RNA factor in class III gene transcription has further changed our thinking in regards to the mechanisms of transcription.

摘要

那些由RNA聚合酶III转录的基因,在其顺式作用元件和反式作用因子方面继续给出令人惊讶的结果。因此,对III类启动子有了更广泛的认识,并且内部启动子在经典的聚合酶III基因中并非普遍存在。TFIID、TFIIA、一种与TFIIB同源的因子以及一种RNA因子参与III类基因转录,这进一步改变了我们对转录机制的看法。

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