Aguilar-Roblero R, Verduzco-Carbajal L, Rodríguez C, Mendez-Franco J, Morán J, de la Mora M P
Departamento de Neurociencias, Universidad Nacional Autonoma de México, México DF.
Neurosci Lett. 1993 Jul 23;157(2):199-202. doi: 10.1016/0304-3940(93)90736-5.
The participation of GABAergic mechanisms in the regulation of circadian rhythmicity by the suprachiasmatic nuclei (SCN) has been suggested from different lines of evidence. Little is known, however, whether GABA synthesis, release, uptake or content within the SCN may show a circadian pattern. The present results show that the activity of the GABAergic system within the SCN region of the rat exhibits circadian rhythmicity, which is manifested by correlative changes of the GABA content and the glutamic acid decarboxylase activity under the light/dark cycle, and by changes in the GABA content in animals kept under constant darkness.
来自不同证据线索表明，γ-氨基丁酸（GABA）能机制参与视交叉上核（SCN）对昼夜节律的调节。然而，关于SCN内GABA的合成、释放、摄取或含量是否呈现昼夜节律模式，人们所知甚少。目前的结果表明，大鼠SCN区域内GABA能系统的活性呈现昼夜节律，这在光/暗周期下表现为GABA含量和谷氨酸脱羧酶活性的相关变化，以及在持续黑暗环境中饲养的动物体内GABA含量的变化。
