Yamamoto M, Sobue G, Mutoh T, Li M, Doyu M, Mitsuma T, Kimata K
Fourth Department of Internal Medicine, Aichi Medical University, Japan.
Neurosci Lett. 1993 Aug 6;158(1):39-43. doi: 10.1016/0304-3940(93)90607-m.
Steady-state mRNA levels and immunoreactive proteins for high- (p140trk) and low-affinity nerve growth factor receptor (LNGFR) in the adult and aged human peripheral nervous system (PNS) were examined in autopsied material. trk mRNA expression was observed only in the sympathetic and dorsal root ganglia, while LNGFR mRNA was expressed widely through the PNS as well as non-neural tissues. Immunoreactive trk proto-oncogene product (p140trk) and LNGFR occurred in the perikarya of the subset of the sympathetic and dorsal root ganglion neurons, but only LNGFR immunoreactivity also occurred in the perineurium and the outer layer of the vessels. The spatial patterns of the trk and LNGFR gene expression in the adult human PNS were similar to those observed in the rat, mouse and chick, and their expression was well preserved in the aged.
在尸检材料中检测了成人和老年人外周神经系统（PNS）中高亲和力（p140trk）和低亲和力神经生长因子受体（LNGFR）的稳态mRNA水平和免疫反应性蛋白。trk mRNA表达仅在交感神经节和背根神经节中观察到，而LNGFR mRNA在整个PNS以及非神经组织中广泛表达。免疫反应性trk原癌基因产物（p140trk）和LNGFR出现在交感神经节和背根神经节神经元亚群的胞体中，但只有LNGFR免疫反应性也出现在神经束膜和血管外层。成人PNS中trk和LNGFR基因表达的空间模式与在大鼠、小鼠和鸡中观察到的相似，并且它们的表达在老年人中保存良好。
