Fukuda K, Hachisuga T, Nakamura S, Matsuo N, Iwasaka T, Sugimori H
Department of Obstetrics and Gynecology, Saga Medical School, Japan.
Obstet Gynecol. 1993 Dec;82(6):941-5.
To investigate the differences in local immune response between persistent and regressive cervical dysplasia.
We conducted a quantitative study of Langerhans cells, pan-T cells, and helper-inducer T cells in the subepithelial connective tissue using immunohistochemical techniques with S-100 protein antibody, UCHL1, and OPD4, respectively, in 52 paraffin sections. The subjects were patients with persistent cervical dysplasia and a comparable control group of 46 patients with regressive dysplasia.
In the subepithelial stroma, the mean (+/- standard deviation) numbers of S-100- and OPD4-positive cells in the persistent group were 8.6 +/- 8.1 and 84.6 +/- 66.3, respectively, compared with 15.1 +/- 9.4 and 147.0 +/- 67.7, respectively, in the regression group. These data demonstrate a significant reduction of Langerhans cells and helper-inducer T cells (P < .0002 and P < .0001, respectively) with persistent dysplasia.
The decreased numbers of S-100-positive Langerhans cells and helper-inducer T cells in persistent dysplasia compared to those of regressive dysplasia strongly support a decreased local immune response in persistent cervical dysplasia.
探讨持续性与消退性宫颈发育异常局部免疫反应的差异。
我们采用免疫组织化学技术，分别用S-100蛋白抗体、UCHL1和OPD4，对52例石蜡切片的上皮下结缔组织中的朗格汉斯细胞、泛T细胞和辅助诱导性T细胞进行了定量研究。研究对象为持续性宫颈发育异常患者以及46例消退性发育异常患者组成的可比对照组。
在持续性组的上皮下基质中，S-100阳性和OPD4阳性细胞的平均（±标准差）数量分别为8.6±8.1和84.6±66.3，而在消退组中分别为15.1±9.4和147.0±67.7。这些数据表明，持续性发育异常时朗格汉斯细胞和辅助诱导性T细胞显著减少（分别为P <.0002和P <.0001）。
与消退性发育异常相比，持续性发育异常中S-100阳性朗格汉斯细胞和辅助诱导性T细胞数量减少，有力地支持了持续性宫颈发育异常时局部免疫反应降低的观点。
