Petersen E, Marbiah N T, Magbiti E, Lines J D, Maude G H, Høgh B, Curtis C, Greenwood B, Bradley D
Laboratory of Parasitology, Statens Seruminstitut, Copenhagen, Denmark.
Parassitologia. 1993 Jul;35 Suppl:81-5.
The effect of lambda-cyhalothrin impregnated bed nets and maloprim/placebo was studied in approximately 1,500 children living in 17 villages in a rural area of Sierra Leone, approximately 150 miles south east of Freetown, 30 miles north of the town of Bo. Villages were selected randomly amongst villages with impregnated bed nets and villages with no nets at all. Within these villages, children with ages ranging between 3 months to 6 years were chosen to receive maloprim or a double-blind distributed placebo fortnightly. In the villages randomised to receive nets, all beds have received nets. Malaria morbidity is estimated from weekly active case detection, and the impact on the Anopheles vector is being estimated by indoor spray catching, exit trap catching, human night landing catches and light trap catches. During the first 8 weeks of the intervention there was a significant reduction in slide positive rates, reported fever rates and children with temperature > or = 37.5 degrees C in the villages with impregnated bed nets.
在塞拉利昂农村地区弗里敦东南约150英里、博城以北30英里处的17个村庄，对约1500名儿童进行了研究，观察了氯氟氰菊酯浸渍蚊帐和乙胺嘧啶/安慰剂的效果。这些村庄是从有浸渍蚊帐的村庄和完全没有蚊帐的村庄中随机挑选出来的。在这些村庄里，年龄在3个月至6岁之间的儿童被挑选出来，每两周接受一次乙胺嘧啶或双盲分发的安慰剂。在随机分配接受蚊帐的村庄里，所有床铺都配备了蚊帐。通过每周的主动病例检测来估计疟疾发病率，并通过室内喷洒捕蚊、出口诱捕、人诱捕和灯光诱捕来估计对按蚊媒介的影响。在干预的前8周，配备浸渍蚊帐的村庄里，血片阳性率、报告的发热率以及体温≥37.5摄氏度的儿童数量都有显著下降。
