Lee A Y, Chen Y T, Lin C J, Wu J P, Chen K S
Department of Medical Research and Cardiology, Taichung Veterans General Hospital, Taiwan, Republic of China.
Proc Natl Sci Counc Repub China B. 1993 Jan;17(1):29-34.
It has been shown that endogenous opioid peptides (EOP) subserve important roles in cardiovascular regulation and are involved in the pathophysiology of myocardial ischemia, contributing to the deleterious effects. The aim of this study was to evaluate the effects of the opiate antagonist naloxone on the hemodynamics and ventricular function following coronary artery occlusion and reperfusion in the dog, utilizing the technique of cardiac catheterization. During myocardial ischemia and reperfusion, it was found that in the control group, there was reduction in the aortic, left ventricular, right atrial, pulmonary arterial and wedge pressures, and in the left ventricular dP/dt. The reduction in the aortic, left ventricular and pulmonary arterial pressures, and left ventricular dP/dt were significantly attenuated by pretreatment with naloxone. The results indicate a regulatory role of EOP in the cardiovascular function and suggest a possible involvement of EOP in myocardial ischemia and reperfusion causing detrimental effects such as arrhythmias, bradycardia, hypotension and, as shown in this study, impaired hemodynamics and ventricular function. The beneficial effects of naloxone on circulatory dynamics may have clinical implications in the prevention and treatment of ischemic heart disease.
研究表明，内源性阿片肽（EOP）在心血管调节中发挥重要作用，并参与心肌缺血的病理生理过程，导致有害影响。本研究的目的是利用心脏导管插入术技术，评估阿片拮抗剂纳洛酮对犬冠状动脉闭塞和再灌注后血流动力学和心室功能的影响。在心肌缺血和再灌注期间，发现在对照组中，主动脉、左心室、右心房、肺动脉和楔压以及左心室dP/dt均降低。纳洛酮预处理可显著减轻主动脉、左心室和肺动脉压以及左心室dP/dt的降低。结果表明EOP在心血管功能中具有调节作用，并提示EOP可能参与心肌缺血和再灌注，导致诸如心律失常、心动过缓、低血压等有害影响，以及如本研究所示的血流动力学和心室功能受损。纳洛酮对循环动力学的有益作用可能对缺血性心脏病的预防和治疗具有临床意义。
