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Naloxone reversal of ischemic arrhythmia is stereospecific and suggests role of endogenous opioid peptides in ischemic heart disease.

作者信息

Kan M N, Chen Y T, Lee A Y

机构信息

Department of Cardiology, Taichung Veterans General Hospital, Taiwan, Republic of China.

出版信息

Proc Soc Exp Biol Med. 1992 Sep;200(4):518-21. doi: 10.3181/00379727-200-43464.

DOI:10.3181/00379727-200-43464
PMID:1508943
Abstract

The effects of the stereoisomers of naloxone during myocardial ischemia were studied. (-)-Naloxone (but not the (+)-isomer naloxone) attenuated the ischemia-induced cardiac arrhythmias, hypotension, and bradycardia that result from coronary artery occlusion in anesthetized rats. From these findings, it may be inferred that endogenous opioid peptides may play a role in the pathophysiology of myocardial ischemia. It is also suggested that naloxone may have therapeutic value in the prevention and treatment of ischemic heart disease.

摘要

相似文献

1
Naloxone reversal of ischemic arrhythmia is stereospecific and suggests role of endogenous opioid peptides in ischemic heart disease.
Proc Soc Exp Biol Med. 1992 Sep;200(4):518-21. doi: 10.3181/00379727-200-43464.
2
Stereospecific antiarrhythmic effects of naloxone against myocardial ischaemia and reperfusion in the dog.纳洛酮对犬心肌缺血及再灌注的立体特异性抗心律失常作用。
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[The development of ischemic cardiac arrhythmias during naloxone blockade of the opiate receptors].[阿片受体纳洛酮阻断期间缺血性心律失常的发生]
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Antiarrhythmic effects of U-50,488H in rats subject to coronary artery occlusion.U-50,488H对冠状动脉闭塞大鼠的抗心律失常作用。
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Naloxone inhibits arrhythmias induced by coronary artery occlusion and reperfusion in anaesthetized dogs.纳洛酮可抑制麻醉犬冠状动脉闭塞和再灌注所诱发的心律失常。
Br J Pharmacol. 1986 Mar;87(3):475-7. doi: 10.1111/j.1476-5381.1986.tb10186.x.
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Antiarrhythmic evaluation of naloxone against acute coronary occlusion-induced arrhythmias in pigs.纳洛酮对猪急性冠状动脉闭塞诱发心律失常的抗心律失常作用评估。
Eur J Pharmacol. 1983 Jun 17;90(4):427-31. doi: 10.1016/0014-2999(83)90566-6.

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