Goldman R S, Axelrod B N, Tandon R, Ribeiro S C, Craig K, Berent S
Department of Veterans Affairs, Ann Arbor, Mich.
Psychopathology. 1993;26(3-4):122-6. doi: 10.1159/000284811.
The present study was conducted to establish the degree of interrelationship between neuropsychological functioning in the acute phase of the schizophrenic illness, clinical measures of treatment response (positive and negative symptoms), and 1-year outcome. Nineteen SADS/RDC schizophrenic inpatients were clinically rated during a 2-week drug washout period and again following 4 weeks of neuroleptic treatment. The findings revealed that reduced attentional ability in the baseline phase significantly predicted the presence of higher residual negative symptoms following 4 weeks of treatment, while neurocognitive status was unrelated to positive symptom response. With respect to prediction of the 1-year outcome, poor functional status of this schizophrenic population was significantly associated with the presence of baseline memory dysfunction.
本研究旨在确定精神分裂症急性期的神经心理功能、治疗反应的临床指标（阳性和阴性症状）与1年预后之间的相互关系程度。19名符合SADS/RDC标准的精神分裂症住院患者在为期2周的药物洗脱期接受临床评估，并在接受4周抗精神病药物治疗后再次评估。研究结果显示，基线期注意力能力下降显著预示着治疗4周后残留阴性症状较多，而神经认知状态与阳性症状反应无关。关于1年预后的预测，该精神分裂症患者群体的功能状态较差与基线记忆功能障碍显著相关。
