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基于径迹结构计算的双链断裂质量评估。

Estimation of double-strand break quality based on track-structure calculations.

作者信息

Michalik V

机构信息

Institute of Radiation, Dosimetry, Czech Republic.

出版信息

Radiat Environ Biophys. 1993;32(3):251-8. doi: 10.1007/BF01209774.

DOI:10.1007/BF01209774
PMID:8234655
Abstract

The aim of this study was to investigate whether double-strand break (DSB) quality is related to the complexity of radiation-induced damage or to the spatial distribution of initial DSBs. The analysis was based on track structure calculations and DNA damage modelling. The results obtained indicate that the quality of DSBs is related to their initial spatial distribution rather than to their complexity.

摘要

本研究的目的是调查双链断裂（DSB）的质量是否与辐射诱导损伤的复杂性或初始DSB的空间分布有关。该分析基于径迹结构计算和DNA损伤建模。所得结果表明，DSB的质量与其初始空间分布有关，而非与其复杂性有关。

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本文引用的文献

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"Trion" code for radiation action calculations and its application in microdosimetry and radiobiology.用于辐射作用计算的“Trion”代码及其在微剂量学和放射生物学中的应用。
Radiat Environ Biophys. 1993;32(1):1-19. doi: 10.1007/BF01213126.
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Energy deposition clusters in nanometer regions of charged-particle tracks.能量沉积聚集在带电粒子径迹的纳米区域。
Radiat Res. 1993 Jun;134(3):265-70.
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Evidence for DNA double-strand breaks as the critical lesions in yeast cells irradiated with sparsely or densely ionizing radiation under oxic or anoxic conditions.
电子和光子径迹中的两种双链断裂及其与交换型染色体畸变的关系。
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Radiat Environ Biophys. 1994;33(1):45-61. doi: 10.1007/BF01255273.
在有氧或无氧条件下，用稀疏或密集电离辐射照射酵母细胞时，DNA双链断裂作为关键损伤的证据。
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The influence of radiation quality and oxygen on strand breakage in dry DNA.辐射质量和氧气对干燥DNA链断裂的影响。
Int J Radiat Biol Relat Stud Phys Chem Med. 1970;18(1):25-40. doi: 10.1080/09553007014550791.
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Lethal and potentially lethal lesions induced by radiation--a unified repair model.辐射诱导的致死性和潜在致死性损伤——一种统一的修复模型。
Radiat Res. 1986 May;106(2):252-70.
6
Effectiveness of 1.5 keV aluminium K and 0.3 keV carbon K characteristic X-rays at inducing DNA double-strand breaks in yeast cells.1.5keV铝K和0.3keV碳K特征X射线诱导酵母细胞DNA双链断裂的有效性。
Int J Radiat Biol Relat Stud Phys Chem Med. 1986 Oct;50(4):727-41. doi: 10.1080/09553008614551121.
7
DNA damage produced by ionizing radiation in mammalian cells: identities, mechanisms of formation, and reparability.电离辐射在哺乳动物细胞中产生的DNA损伤：特性、形成机制及可修复性。
Prog Nucleic Acid Res Mol Biol. 1988;35:95-125. doi: 10.1016/s0079-6603(08)60611-x.
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DNA double-strand break repair determines the RBE of alpha-particles.
Int J Radiat Biol. 1988 Nov;54(5):761-71. doi: 10.1080/09553008814552201.
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The initial physical damage produced by ionizing radiations.电离辐射产生的初始物理损伤。
Int J Radiat Biol. 1989 Nov;56(5):623-34. doi: 10.1080/09553008914551841.
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Induction, repair and biological relevance of radiation-induced DNA lesions in eukaryotic cells.真核细胞中辐射诱导的DNA损伤的诱导、修复及生物学相关性
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