鸡毛细胞中的传出突触机制。

Efferent synapse mechanisms in chick hair cells.

作者信息

Ohmori H

机构信息

Department of Physiology, Faculty of Medicine, University of Kyoto, Japan.

出版信息

Prog Brain Res. 1993;97:7-11. doi: 10.1016/s0079-6123(08)62257-8.

DOI:10.1016/s0079-6123(08)62257-8

PMID:8234769

Abstract

Electrical stimulation of the efferent fiber to the hair cell is known to suppress peripheral auditory function. In isolated hair cells from the chick, acetylcholine (ACh) generated membrane hyperpolarization when a puff was applied at concentrations from 1 microM to 5 mM. Ionophoretic application of ACh generated a membrane hyperpolarization with a rapid time course. This is due to the increase of K conductance and is accompanied by the rise of the [Ca]i.

摘要

已知对毛细胞传出纤维进行电刺激会抑制外周听觉功能。在从雏鸡分离出的毛细胞中，当以1微摩尔至5毫摩尔的浓度微量注射乙酰胆碱（ACh）时，会产生膜超极化。离子电泳施加ACh会产生具有快速时间进程的膜超极化。这是由于钾电导增加所致，并伴随着细胞内钙离子浓度（[Ca]i）的升高。