传出性内侧橄榄耳蜗-毛细胞突触。
The efferent medial olivocochlear-hair cell synapse.
作者信息
Elgoyhen Ana Belén, Katz Eleonora
机构信息
Instituto de Investigaciones en Ingeniería Genética y Biología Molecular, Consejo Nacional de Investigaciones Científicas y Técnicas, Argentina.
出版信息
J Physiol Paris. 2012 Jan;106(1-2):47-56. doi: 10.1016/j.jphysparis.2011.06.001. Epub 2011 Jul 6.
Abstract
Amplification of incoming sounds in the inner ear is modulated by an efferent pathway which travels back from the brain all the way to the cochlea. The medial olivocochlear system makes synaptic contacts with hair cells, where the neurotransmitter acetylcholine is released. Synaptic transmission is mediated by a unique nicotinic cholinergic receptor composed of α9 and α10 subunits, which is highly Ca2+ permeable and is coupled to a Ca2+-activated SK potassium channel. Thus, hyperpolarization of hair cells follows efferent fiber activation. In this work we review the literature that has enlightened our knowledge concerning the intimacies of this synapse.
摘要
内耳中传入声音的放大是由一条从大脑一直延伸到耳蜗的传出通路调节的。内侧橄榄耳蜗系统与毛细胞形成突触联系，在那里释放神经递质乙酰胆碱。突触传递由一种独特的烟碱型胆碱能受体介导，该受体由α9和α10亚基组成，具有高度的Ca2+通透性，并与Ca2+激活的SK钾通道偶联。因此，传出纤维激活后毛细胞会发生超极化。在这项工作中，我们回顾了相关文献，这些文献增进了我们对这个突触细节的了解。
相似文献
1
The efferent medial olivocochlear-hair cell synapse.传出性内侧橄榄耳蜗-毛细胞突触。
J Physiol Paris. 2012 Jan;106(1-2):47-56. doi: 10.1016/j.jphysparis.2011.06.001. Epub 2011 Jul 6.
2
The alpha10 nicotinic acetylcholine receptor subunit is required for normal synaptic function and integrity of the olivocochlear system.α10烟碱型乙酰胆碱受体亚基是橄榄耳蜗系统正常突触功能和完整性所必需的。
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Strengthening of the Efferent Olivocochlear System Leads to Synaptic Dysfunction and Tonotopy Disruption of a Central Auditory Nucleus.传出橄榄耳蜗系统的增强导致中枢听觉核的突触功能障碍和音位错位。
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本文引用的文献
1
A randomized, double-blind, placebo-controlled clinical trial to evaluate the efficacy and safety of neramexane in patients with moderate to severe subjective tinnitus.一项评估奈拉米克对中重度主观性耳鸣患者疗效和安全性的随机、双盲、安慰剂对照临床试验。
BMC Ear Nose Throat Disord. 2011 Jan 11;11:1. doi: 10.1186/1472-6815-11-1.
2
BK channels mediate cholinergic inhibition of high frequency cochlear hair cells.BK 通道介导胆碱能抑制高频耳蜗毛细胞。
PLoS One. 2010 Nov 4;5(11):e13836. doi: 10.1371/journal.pone.0013836.
3
From zebrafish to mammal: functional evolution of prestin, the motor protein of cochlear outer hair cells.从斑马鱼到哺乳动物：耳蜗外毛细胞运动蛋白 prestin 的功能进化。
J Neurophysiol. 2011 Jan;105(1):36-44. doi: 10.1152/jn.00234.2010. Epub 2010 Nov 3.
4
The olivary peduncle and other fiber projections of the superior olivary complex.橄榄脚及上橄榄复合体的其他纤维投射。
J Comp Neurol. 1946 Apr;84:141-219. doi: 10.1002/cne.900840204.
5
Ca2+-activated K+ channels: from protein complexes to function.钙激活钾通道：从蛋白复合物到功能。
Physiol Rev. 2010 Oct;90(4):1437-59. doi: 10.1152/physrev.00049.2009.
6
Ca(2+) and Ca(2+)-activated K(+) channels that support and modulate transmitter release at the olivocochlear efferent-inner hair cell synapse.支持并调节橄榄耳蜗传出-内毛细胞突触递质释放的 Ca(2+) 和 Ca(2+)-激活的 K(+) 通道。
J Neurosci. 2010 Sep 8;30(36):12157-67. doi: 10.1523/JNEUROSCI.2541-10.2010.
7
Calcium action potentials in hair cells pattern auditory neuron activity before hearing onset.毛细胞中的钙动作电位在听觉神经元活动开始前对其进行模式化。
Nat Neurosci. 2010 Sep;13(9):1050-2. doi: 10.1038/nn.2604. Epub 2010 Aug 1.
8
Developmental regulation of spontaneous activity in the Mammalian cochlea.哺乳动物耳蜗中自发性活动的发育调控。
J Neurosci. 2010 Jan 27;30(4):1539-50. doi: 10.1523/JNEUROSCI.3875-09.2010.
9
Prestin and the cholinergic receptor of hair cells: positively-selected proteins in mammals.耳蝸 prestin 和其胆碱能受體：哺乳動物中受正選擇的蛋白質。
Hear Res. 2011 Mar;273(1-2):100-8. doi: 10.1016/j.heares.2009.12.028. Epub 2010 Jan 6.
10
Pharmacological approaches to the treatment of tinnitus.耳鸣的药物治疗方法。
Drug Discov Today. 2010 Apr;15(7-8):300-5. doi: 10.1016/j.drudis.2009.11.003. Epub 2009 Dec 2.
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