传出性内侧橄榄耳蜗-毛细胞突触。
The efferent medial olivocochlear-hair cell synapse.
作者信息
Elgoyhen Ana Belén, Katz Eleonora
机构信息
Instituto de Investigaciones en Ingeniería Genética y Biología Molecular, Consejo Nacional de Investigaciones Científicas y Técnicas, Argentina.
出版信息
J Physiol Paris. 2012 Jan;106(1-2):47-56. doi: 10.1016/j.jphysparis.2011.06.001. Epub 2011 Jul 6.
Abstract
Amplification of incoming sounds in the inner ear is modulated by an efferent pathway which travels back from the brain all the way to the cochlea. The medial olivocochlear system makes synaptic contacts with hair cells, where the neurotransmitter acetylcholine is released. Synaptic transmission is mediated by a unique nicotinic cholinergic receptor composed of α9 and α10 subunits, which is highly Ca2+ permeable and is coupled to a Ca2+-activated SK potassium channel. Thus, hyperpolarization of hair cells follows efferent fiber activation. In this work we review the literature that has enlightened our knowledge concerning the intimacies of this synapse.
摘要
内耳中传入声音的放大是由一条从大脑一直延伸到耳蜗的传出通路调节的。内侧橄榄耳蜗系统与毛细胞形成突触联系，在那里释放神经递质乙酰胆碱。突触传递由一种独特的烟碱型胆碱能受体介导，该受体由α9和α10亚基组成，具有高度的Ca2+通透性，并与Ca2+激活的SK钾通道偶联。因此，传出纤维激活后毛细胞会发生超极化。在这项工作中，我们回顾了相关文献，这些文献增进了我们对这个突触细节的了解。
相似文献
1
The efferent medial olivocochlear-hair cell synapse.
J Physiol Paris. 2012 Jan;106(1-2):47-56. doi: 10.1016/j.jphysparis.2011.06.001. Epub 2011 Jul 6.
2
The alpha10 nicotinic acetylcholine receptor subunit is required for normal synaptic function and integrity of the olivocochlear system.
Proc Natl Acad Sci U S A. 2007 Dec 18;104(51):20594-9. doi: 10.1073/pnas.0708545105. Epub 2007 Dec 12.
3
Strengthening of the Efferent Olivocochlear System Leads to Synaptic Dysfunction and Tonotopy Disruption of a Central Auditory Nucleus.
J Neurosci. 2019 Sep 4;39(36):7037-7048. doi: 10.1523/JNEUROSCI.2536-18.2019. Epub 2019 Jun 19.
4
Unraveling the Molecular Players at the Cholinergic Efferent Synapse of the Zebrafish Lateral Line.
J Neurosci. 2021 Jan 6;41(1):47-60. doi: 10.1523/JNEUROSCI.1772-20.2020. Epub 2020 Nov 17.
5
A Gain-of-Function Mutation in the α9 Nicotinic Acetylcholine Receptor Alters Medial Olivocochlear Efferent Short-Term Synaptic Plasticity.
J Neurosci. 2018 Apr 18;38(16):3939-3954. doi: 10.1523/JNEUROSCI.2528-17.2018. Epub 2018 Mar 23.
6
Role of alpha9 nicotinic ACh receptor subunits in the development and function of cochlear efferent innervation.
Neuron. 1999 May;23(1):93-103. doi: 10.1016/s0896-6273(00)80756-4.
7
Enhancement of the Medial Olivocochlear System Prevents Hidden Hearing Loss.
J Neurosci. 2018 Aug 22;38(34):7440-7451. doi: 10.1523/JNEUROSCI.0363-18.2018. Epub 2018 Jul 20.
8
The nicotinic receptor of cochlear hair cells: a possible pharmacotherapeutic target?
Biochem Pharmacol. 2009 Oct 1;78(7):712-9. doi: 10.1016/j.bcp.2009.05.023. Epub 2009 May 27.
9
Onset of cholinergic efferent synaptic function in sensory hair cells of the rat cochlea.
J Neurosci. 2011 Oct 19;31(42):15092-101. doi: 10.1523/JNEUROSCI.2743-11.2011.
10
Voltage-Gated Calcium Influx Modifies Cholinergic Inhibition of Inner Hair Cells in the Immature Rat Cochlea.
J Neurosci. 2018 Jun 20;38(25):5677-5687. doi: 10.1523/JNEUROSCI.0230-18.2018. Epub 2018 May 22.
引用本文的文献
1
Virally mediated enhancement of efferent inhibition reduces acoustic trauma in wild-type murine cochleas.
Mol Ther Methods Clin Dev. 2025 Mar 21;33(2):101455. doi: 10.1016/j.omtm.2025.101455. eCollection 2025 Jun 12.
2
Flupyradifurone, imidacloprid and clothianidin disrupt the auditory processing in the locust CNS.
J Comp Physiol A Neuroethol Sens Neural Behav Physiol. 2025 May;211(3):311-325. doi: 10.1007/s00359-025-01735-8. Epub 2025 Feb 13.
3
Placode and neural crest origins of congenital deafness in mouse models of Waardenburg-Shah syndrome.
iScience. 2024 Dec 24;28(1):111680. doi: 10.1016/j.isci.2024.111680. eCollection 2025 Jan 17.
4
Virally-Mediated Enhancement of Efferent Inhibition Reduces Acoustic Trauma in Wild Type Murine Cochleas.
bioRxiv. 2024 Sep 15:2024.09.12.612688. doi: 10.1101/2024.09.12.612688.
5
Key role of the TM2-TM3 loop in calcium potentiation of the α9α10 nicotinic acetylcholine receptor.
Cell Mol Life Sci. 2024 Aug 9;81(1):337. doi: 10.1007/s00018-024-05381-2.
6
Explorations of Agonist Selectivity for the α9* nAChR with Novel Substituted Carbamoyl/Amido/Heteroaryl Dialkylpiperazinium Salts and Their Therapeutic Implications in Pain and Inflammation.
J Med Chem. 2024 Jun 13;67(11):8642-8666. doi: 10.1021/acs.jmedchem.3c02429. Epub 2024 May 15.
7
Contributions of Non-Neuronal Cholinergic Systems to the Regulation of Immune Cell Function, Highlighting the Role of α7 Nicotinic Acetylcholine Receptors.
Int J Mol Sci. 2024 Apr 22;25(8):4564. doi: 10.3390/ijms25084564.
8
The Remarkable Outer Hair Cell: Proceedings of a Symposium in Honour of W. E. Brownell.
J Assoc Res Otolaryngol. 2023 Apr;24(2):117-127. doi: 10.1007/s10162-022-00852-4. Epub 2023 Jan 17.
9
Corticofugal and Brainstem Functions Associated With Medial Olivocochlear Cholinergic Transmission.
Front Neurosci. 2022 Apr 27;16:866161. doi: 10.3389/fnins.2022.866161. eCollection 2022.
10
α9-Containing Nicotinic Receptors in Cancer.
Front Cell Neurosci. 2022 Jan 21;15:805123. doi: 10.3389/fncel.2021.805123. eCollection 2021.
本文引用的文献
1
A randomized, double-blind, placebo-controlled clinical trial to evaluate the efficacy and safety of neramexane in patients with moderate to severe subjective tinnitus.
BMC Ear Nose Throat Disord. 2011 Jan 11;11:1. doi: 10.1186/1472-6815-11-1.
2
BK channels mediate cholinergic inhibition of high frequency cochlear hair cells.
PLoS One. 2010 Nov 4;5(11):e13836. doi: 10.1371/journal.pone.0013836.
3
From zebrafish to mammal: functional evolution of prestin, the motor protein of cochlear outer hair cells.
J Neurophysiol. 2011 Jan;105(1):36-44. doi: 10.1152/jn.00234.2010. Epub 2010 Nov 3.
4
The olivary peduncle and other fiber projections of the superior olivary complex.
J Comp Neurol. 1946 Apr;84:141-219. doi: 10.1002/cne.900840204.
5
Ca2+-activated K+ channels: from protein complexes to function.
Physiol Rev. 2010 Oct;90(4):1437-59. doi: 10.1152/physrev.00049.2009.
6
Ca(2+) and Ca(2+)-activated K(+) channels that support and modulate transmitter release at the olivocochlear efferent-inner hair cell synapse.
J Neurosci. 2010 Sep 8;30(36):12157-67. doi: 10.1523/JNEUROSCI.2541-10.2010.
7
Calcium action potentials in hair cells pattern auditory neuron activity before hearing onset.
Nat Neurosci. 2010 Sep;13(9):1050-2. doi: 10.1038/nn.2604. Epub 2010 Aug 1.
8
Developmental regulation of spontaneous activity in the Mammalian cochlea.
J Neurosci. 2010 Jan 27;30(4):1539-50. doi: 10.1523/JNEUROSCI.3875-09.2010.
9
Prestin and the cholinergic receptor of hair cells: positively-selected proteins in mammals.
Hear Res. 2011 Mar;273(1-2):100-8. doi: 10.1016/j.heares.2009.12.028. Epub 2010 Jan 6.
10
Pharmacological approaches to the treatment of tinnitus.
Drug Discov Today. 2010 Apr;15(7-8):300-5. doi: 10.1016/j.drudis.2009.11.003. Epub 2009 Dec 2.
Zotero 插件