Elgoyhen Ana Belén, Katz Eleonora
Instituto de Investigaciones en Ingeniería Genética y Biología Molecular, Consejo Nacional de Investigaciones Científicas y Técnicas, Argentina.
J Physiol Paris. 2012 Jan;106(1-2):47-56. doi: 10.1016/j.jphysparis.2011.06.001. Epub 2011 Jul 6.
Amplification of incoming sounds in the inner ear is modulated by an efferent pathway which travels back from the brain all the way to the cochlea. The medial olivocochlear system makes synaptic contacts with hair cells, where the neurotransmitter acetylcholine is released. Synaptic transmission is mediated by a unique nicotinic cholinergic receptor composed of α9 and α10 subunits, which is highly Ca2+ permeable and is coupled to a Ca2+-activated SK potassium channel. Thus, hyperpolarization of hair cells follows efferent fiber activation. In this work we review the literature that has enlightened our knowledge concerning the intimacies of this synapse.
内耳中传入声音的放大是由一条从大脑一直延伸到耳蜗的传出通路调节的。内侧橄榄耳蜗系统与毛细胞形成突触联系，在那里释放神经递质乙酰胆碱。突触传递由一种独特的烟碱型胆碱能受体介导，该受体由α9和α10亚基组成，具有高度的Ca2+通透性，并与Ca2+激活的SK钾通道偶联。因此，传出纤维激活后毛细胞会发生超极化。在这项工作中，我们回顾了相关文献，这些文献增进了我们对这个突触细节的了解。
